CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-040501
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Integrin beta 
Protein Synonyms/Alias
  
Gene Name
 Itgb2 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Rattus norvegicus (Rat) 
NCBI Taxa ID
 10116 
Lysine Modification
Position
Peptide
Type
References
357SNVVQLIKKAYYKLSacetylation[1]
754NNDNPLFKSATTTVMubiquitination[2]
Reference
 [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405]
 [2] Synaptic protein ubiquitination in rat brain revealed by antibody-based ubiquitome analysis.
 Na CH, Jones DR, Yang Y, Wang X, Xu Y, Peng J.
 J Proteome Res. 2012 Sep 7;11(9):4722-32. [PMID: 22871113] 
Functional Description
  
Sequence Annotation
  
Keyword
 Cell adhesion; Complete proteome; Integrin; Membrane; Reference proteome; Transmembrane. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 768 AA 
Protein Sequence
MLGPHTLLLI LAGLLFLGSA LSEECTKYKV SNCRDCIQSG PGCSWCQKLN FTGPGEPDSL 60
RCDTRAQLLL KGCPADDIMD PKSFADLHPQ YQVQRSQLSP QKVTLNLRPG QAAAFNVTFR 120
RAKGYPIDLY YLMDLSYSML DDLNNVKKLG GDLLQALNEI TESGRIGFGS FVDKTVLPFV 180
NTHPEKLRNP CPNKEKACQP PFAFRHVLKL TDNSNQFQTE VGKQLISGNL DAPEGGLDAI 240
MQVAACPEFI FPVSVTLCLS FATDDGFHFA GDGKLGAILT PNDGRCHLED NMYKRSNEFD 300
YPSVGQLAHK LSESNIQPIF AVTKKMVKTY EKLTEIIPKS AVGELSDDSS NVVQLIKKAY 360
YKLSSRVFLD HTTIPDTLKV TYDSFCNNRV SSIGKSRGDC DGVQINNPVT FQVKVTASEC 420
IQEQSFVIRA LGFTDTVTVQ VHPQCECQCR DQSRMRNLCG GKGVMECGIC RCESGYIGKN 480
CECQTQGRSS QELEGNCRKD NSSIVCSGLG DCICGQCVCH TSDIPNKVIF GQYCECDNFN 540
CERYDGQVCG GLKRGSCSCG QCNCKEGFEG SACQCQRSTT GCLNARLVEC SGRGRCQCNR 600
CICEKGYQPP LCEECPGCPL PCSTYVFCAE CLKFDKGPFQ KNCSVQCANV TLQTVPFKKK 660
PCKERDSEGC WITYTLQQKD GNAYNIHVDD DRECVKGPNV AAIIGGTVAG VVLIGVLLLV 720
IWKALTHLTD LNEYRRFEKE KLKSQWNNDN PLFKSATTTV MNPKFAES 768 
Gene Ontology
 GO:0009986; C:cell surface; IDA:RGD.
 GO:0008305; C:integrin complex; IEA:InterPro.
 GO:0005886; C:plasma membrane; IDA:RGD.
 GO:0004872; F:receptor activity; IEA:InterPro.
 GO:0007568; P:aging; IEP:RGD.
 GO:0007160; P:cell-matrix adhesion; IEA:InterPro.
 GO:0045123; P:cellular extravasation; IMP:RGD.
 GO:0043542; P:endothelial cell migration; IMP:RGD.
 GO:0007229; P:integrin-mediated signaling pathway; IEA:UniProtKB-KW.
 GO:0007159; P:leukocyte cell-cell adhesion; IMP:RGD.
 GO:0002523; P:leukocyte migration involved in inflammatory response; IMP:RGD.
 GO:0007275; P:multicellular organismal development; IEA:InterPro.
 GO:0030101; P:natural killer cell activation; IMP:RGD.
 GO:0045766; P:positive regulation of angiogenesis; IMP:RGD.
 GO:0051092; P:positive regulation of NF-kappaB transcription factor activity; IMP:RGD.
 GO:0045429; P:positive regulation of nitric oxide biosynthetic process; IMP:RGD. 
Interpro
 IPR015812; Integrin_bsu.
 IPR015439; Integrin_bsu-2.
 IPR014836; Integrin_bsu_cyt_dom.
 IPR002369; Integrin_bsu_N.
 IPR012896; Integrin_bsu_tail.
 IPR003659; Plexin-like.
 IPR016201; Plexin-like_fold.
 IPR002035; VWF_A. 
Pfam
 PF08725; Integrin_b_cyt
 PF07965; Integrin_B_tail
 PF00362; Integrin_beta 
SMART
 SM00187; INB
 SM00423; PSI
 SM00327; VWA 
PROSITE
 PS00243; INTEGRIN_BETA 
PRINTS
 PR01186; INTEGRINB.