CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-018057
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Acid phosphatase-like protein 2 
Protein Synonyms/Alias
  
Gene Name
 ACPL2 
Gene Synonyms/Alias
 UNQ370/PRO706 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
110LYVIPKTKRPEIDCTubiquitination[1]
189DIYLKKHKLLPNDWSubiquitination[1]
256VRNQYLEKEQRRQYLubiquitination[1]
287KIVDVPTKQLRAANPubiquitination[1, 2]
325MEHFKVIKTHQIEDEubiquitination[1]
444DHHKRSPKPMCPLENubiquitination[1]
Reference
 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition.
 Udeshi ND, Mani DR, Eisenhaure T, Mertins P, Jaffe JD, Clauser KR, Hacohen N, Carr SA.
 Mol Cell Proteomics. 2012 May;11(5):148-59. [PMID: 22505724] 
Functional Description
  
Sequence Annotation
 ACT_SITE 97 97 Nucleophile (By similarity).
 ACT_SITE 379 379 Proton donor (By similarity).
 CARBOHYD 305 305 N-linked (GlcNAc...) (Potential).  
Keyword
 Alternative splicing; Complete proteome; Glycoprotein; Hydrolase; Reference proteome; Secreted; Signal. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 480 AA 
Protein Sequence
MLFRNRFLLL LALAALLAFV SLSLQFFHLI PVSTPKNGMS SKSRKRIMPD PVTEPPVTDP 60
VYEALLYCNI PSVAERSMEG HAPHHFKLVS VHVFIRHGDR YPLYVIPKTK RPEIDCTLVA 120
NRKPYHPKLE AFISHMSKGS GASFESPLNS LPLYPNHPLC EMGELTQTGV VQHLQNGQLL 180
RDIYLKKHKL LPNDWSADQL YLETTGKSRT LQSGLALLYG FLPDFDWKKI YFRHQPSALF 240
CSGSCYCPVR NQYLEKEQRR QYLLRLKNSQ LEKTYGEMAK IVDVPTKQLR AANPIDSMLC 300
HFCHNVSFPC TRNGCVDMEH FKVIKTHQIE DERERREKKL YFGYSLLGAH PILNQTIGRM 360
QRATEGRKEE LFALYSAHDV TLSPVLSALG LSEARFPRFA ARLIFELWQD REKPSEHSVR 420
ILYNGVDVTF HTSFCQDHHK RSPKPMCPLE NLVRFVKRDM FVALGGSGTN YYDACHREGF 480 
Gene Ontology
 GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
 GO:0003993; F:acid phosphatase activity; IEA:EC. 
Interpro
 IPR000560; His_Pase_superF_clade-2. 
Pfam
 PF00328; His_Phos_2 
SMART
  
PROSITE
 PS00616; HIS_ACID_PHOSPHAT_1
 PS00778; HIS_ACID_PHOSPHAT_2 
PRINTS