CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-044003
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Methyltransferase-like protein 2B 
Protein Synonyms/Alias
  
Gene Name
 METTL2B 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
85IHENGFFKDRHWLFTubiquitination[1]
107SQNQNHLKDWFLENKmethylation[2]
140EQHKCSSKSLEHKTQubiquitination[1]
145SSKSLEHKTQTPPVEubiquitination[3, 4]
Reference
 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] Large-scale global identification of protein lysine methylation in vivo.
 Cao XJ, Arnaudo AM, Garcia BA.
 Epigenetics. 2013 May 1;8(5):477-85. [PMID: 23644510]
 [3] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [4] Global identification of modular cullin-RING ligase substrates.
 Emanuele MJ, Elia AE, Xu Q, Thoma CR, Izhar L, Leng Y, Guo A, Chen YN, Rush J, Hsu PW, Yen HC, Elledge SJ.
 Cell. 2011 Oct 14;147(2):459-74. [PMID: 21963094
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 235 AA 
Protein Sequence
RGYKGRRLGG VALRSAADGA FVSGEFCGGK LLRWCLVTDF PPDSCTTCSY SRRSTPGCSP 60
GVDYEINAHK YWNDFYKIHE NGFFKDRHWL FTEFPELAPS QNQNHLKDWF LENKSEVCEC 120
RNNEDGPGLI MEEQHKCSSK SLEHKTQTPP VEENVTQKIS DLEICADEFP GSSATYRILE 180
VGCGVGNTVF PILQTNNDPG LFVYCCDFSS TAIELVQTNS EYDPSRCFAF VHDLC 235 
Gene Ontology
  
Interpro
 IPR026113; MeTrfase. 
Pfam
  
SMART
  
PROSITE
  
PRINTS