CPLM-020047

Genbank Nucleotide ID

Protein Synonyms/Alias

SelS; VCP-interacting membrane protein

Homo sapiens (Human)

Position	Peptide	Type	References
77	VEPDVVVKRQEALAA	ubiquitination	[1, 2, 3, 4]
88	ALAAARLKMQEELNA	ubiquitination	[2]
134	SYKGNAKKPQEEDSP	ubiquitination	[2, 4]
150	PSTSSVLKRKSDRKP	ubiquitination	[2, 4]

[1] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
[2] Systematic and quantitative assessment of the ubiquitin-modified proteome.
Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
[3] Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition.
Udeshi ND, Mani DR, Eisenhaure T, Mertins P, Jaffe JD, Clauser KR, Hacohen N, Carr SA.
Mol Cell Proteomics. 2012 May;11(5):148-59. [PMID: 22505724]
[4] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661]

Functional Description

Involved in the degradation process of misfolded endoplasmic reticulum (ER) luminal proteins. Participates in the transfer of misfolded proteins from the ER to the cytosol, where they are destroyed by the proteasome in a ubiquitin-dependent manner. Probably acts by serving as a linker between DERL1, which mediates the retrotranslocation of misfolded proteins into the cytosol, and the ATPase complex VCP, which mediates the translocation and ubiquitination.

MOD_RES 140 140 Phosphoserine.

3D-structure; Complete proteome; Cytoplasm; Endoplasmic reticulum; Membrane; Phosphoprotein; Reference proteome; Selenocysteine; Transmembrane; Transmembrane helix.

UniProt (SWISSPROT/TrEMBL); GenBank; EMBL

GO:0005881; C:cytoplasmic microtubule; IDA:UniProtKB.
GO:0030176; C:integral to endoplasmic reticulum membrane; IDA:UniProtKB.
GO:0034362; C:low-density lipoprotein particle; IDA:BHF-UCL.
GO:0005886; C:plasma membrane; TAS:BHF-UCL.
GO:0034361; C:very-low-density lipoprotein particle; IDA:BHF-UCL.
GO:0016209; F:antioxidant activity; IDA:UniProtKB.
GO:0004872; F:receptor activity; NAS:UniProtKB.
GO:0008430; F:selenium binding; IEA:InterPro.
GO:0045454; P:cell redox homeostasis; IDA:UniProtKB.
GO:0032869; P:cellular response to insulin stimulus; TAS:BHF-UCL.
GO:0071222; P:cellular response to lipopolysaccharide; IMP:BHF-UCL.
GO:0034599; P:cellular response to oxidative stress; IMP:BHF-UCL.
GO:0030968; P:endoplasmic reticulum unfolded protein response; IDA:UniProtKB.
GO:0006983; P:ER overload response; IDA:BHF-UCL.
GO:0030433; P:ER-associated protein catabolic process; IDA:UniProtKB.
GO:0002865; P:negative regulation of acute inflammatory response to antigenic stimulus; IMP:BHF-UCL.
GO:0043066; P:negative regulation of apoptotic process; IMP:BHF-UCL.
GO:0046325; P:negative regulation of glucose import; TAS:BHF-UCL.
GO:0045719; P:negative regulation of glycogen biosynthetic process; TAS:BHF-UCL.
GO:0032715; P:negative regulation of interleukin-6 production; ISS:BHF-UCL.
GO:0051771; P:negative regulation of nitric-oxide synthase biosynthetic process; IMP:BHF-UCL.
GO:0032720; P:negative regulation of tumor necrosis factor production; ISS:BHF-UCL.
GO:0006111; P:regulation of gluconeogenesis; TAS:BHF-UCL.
GO:0080164; P:regulation of nitric oxide metabolic process; IMP:BHF-UCL.
GO:0009749; P:response to glucose stimulus; IEP:UniProtKB.
GO:0051775; P:response to redox state; IDA:UniProtKB.
GO:0030970; P:retrograde protein transport, ER to cytosol; IDA:UniProtKB.

IPR009703; Selenoprotein_S.

PF06936; Selenoprotein_S