CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-042659
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Ribonucleoside-diphosphate reductase subunit M2 B 
Protein Synonyms/Alias
  
Gene Name
 RRM2B 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
85DTNESEIKSNEEPLLubiquitination[1]
223IETMPYVKKKADWALubiquitination[1]
224ETMPYVKKKADWALRubiquitination[2]
383GKTNFFEKRVSEYQRubiquitination[1, 2, 3, 4]
Reference
 [1] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [2] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [3] Global identification of modular cullin-RING ligase substrates.
 Emanuele MJ, Elia AE, Xu Q, Thoma CR, Izhar L, Leng Y, Guo A, Chen YN, Rush J, Hsu PW, Yen HC, Elledge SJ.
 Cell. 2011 Oct 14;147(2):459-74. [PMID: 21963094]
 [4] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302] 
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 408 AA 
Protein Sequence
XDCKLQDRCR KCYSPRSGQA CPPALAAAWL RRCERRGGRP RGGRRKELTL GLRPARCSAP 60
GPAKDDAWRP QAGRSSSDTN ESEIKSNEEP LLRKSSRRFV IFPIQYPDIW KMYKQAQASF 120
WTAEEVDLSK DLPHWNKLKA DEKYFISHIL AFFAASDGIV NENLVERFSQ EVQVPEARCF 180
YGFQILIENV HSEMYSLLID TYIRDPKKRE FLFNAIETMP YVKKKADWAL RWIADRKSTF 240
GERVVAFAAV EGVFFSGSFA AIFWLKKRGL MPGLTFSNEL ISRDEGLHCD FACLMFQYLV 300
NKPSEERVRE IIVDAVKIEQ EFLTEALPVG LIGMNCILMK QYIEFVADRL LVELGFSKVF 360
QAENPFDFME NISLEGKTNF FEKRVSEYQR FAVMAETTDN VFTLDADF 408 
Gene Ontology
 GO:0016491; F:oxidoreductase activity; IEA:InterPro.
 GO:0046914; F:transition metal ion binding; IEA:InterPro.
 GO:0009186; P:deoxyribonucleoside diphosphate metabolic process; IEA:InterPro. 
Interpro
 IPR009078; Ferritin-like_SF.
 IPR012348; RNR-rel.
 IPR000358; RNR_small. 
Pfam
 PF00268; Ribonuc_red_sm 
SMART
  
PROSITE
 PS00368; RIBORED_SMALL 
PRINTS