UniProt Accession

 PEP12_YEAST; P32854; D6W2A3 

Genbank Protein ID

 M90395; X87331; Z74944; BK006948 

Genbank Nucleotide ID

 AAB38370.1; CAA60755.1; CAA99226.1; DAA10819.1 

Protein Name

 Syntaxin PEP12 

Protein Synonyms/Alias

 Carboxypeptidase Y-deficient protein 12; Vacuolar protein sorting-associated protein 6; Vacuolar protein-targeting protein 13 

Gene Name

 PEP12 

Gene Synonyms/Alias

 VPS6; VPT13; YOR036W; OR26.29 

Created Date

 July 27, 2013 

Organism

 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) 

NCBI Taxa ID

 559292 

Lysine Modification

Position	Peptide	Type	References
145	KQVNERAKESLEASE	ubiquitination	[1]
220	TELNEVFKDLGSVVQ	ubiquitination	[2]

Reference

 [1] Global analysis of phosphorylation and ubiquitylation cross-talk in protein degradation.
 Swaney DL, Beltrao P, Starita L, Guo A, Rush J, Fields S, Krogan NJ, Villén J.
 Nat Methods. 2013 Jul;10(7):676-82. [PMID: 23749301]
 [2] Identification, analysis, and prediction of protein ubiquitination sites.
 Radivojac P, Vacic V, Haynes C, Cocklin RR, Mohan A, Heyen JW, Goebl MG, Iakoucheva LM.
 Proteins. 2010 Feb 1;78(2):365-80. [PMID: 19722269] 

Functional Description

 Plays a role in the sorting and targeting of vacuolar proteases. 

Sequence Annotation

 DOMAIN 195 257 t-SNARE coiled-coil homology.
 MOD_RES 2 2 Phosphoserine.
 MOD_RES 23 23 Phosphoserine.  

Keyword

 Coiled coil; Complete proteome; Membrane; Phosphoprotein; Reference proteome; Transmembrane; Transmembrane helix; Ubl conjugation. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 288 AA 

Protein Sequence

Gene Ontology

 GO:0005768; C:endosome; IMP:SGD.
 GO:0005794; C:Golgi apparatus; IMP:SGD.
 GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
 GO:0005484; F:SNAP receptor activity; IDA:SGD.
 GO:0006896; P:Golgi to vacuole transport; IMP:SGD.
 GO:0006886; P:intracellular protein transport; IEA:InterPro.
 GO:0000011; P:vacuole inheritance; IMP:SGD. 

Interpro

 IPR006012; Syntaxin/epimorphin_CS.
 IPR006011; Syntaxin_N.
 IPR010989; t-SNARE.
 IPR000727; T_SNARE_dom. 

Pfam

 PF05739; SNARE 

SMART

 SM00503; SynN
 SM00397; t_SNARE 

PROSITE

 PS00914; SYNTAXIN
 PS50192; T_SNARE 

PRINTS