CPLM-015328

CPLM 1.0 - Compendium of Protein Lysine Modification

Tag

Content

CPLM ID

CPLM-015328

UniProt Accession

ZC3HE_HUMAN; Q6PJT7; A8MY46; B4E2H4; G3V5R4; Q6MZU4; Q6PJ32; Q6PUI6; Q6PUI8; Q86TQ5; Q86TW0; Q86TW1; Q8NCT6; Q8NCZ3; Q8TDE2; Q9HAC9; Q9Y5A0

Genbank Protein ID

AF474376; AY578060; AY578061; AY578062; AY578063; AK021868; AK304275; AL834215; BX640716; BX640876; AL162171; CH471061; CH471061; CH471061; CH471061; BC011793; BC023641; BC027607; BX248265; BX248281; BX248769; AF155107

Genbank Nucleotide ID

AAL83289.1; AAS90299.1; AAS90300.1; AAS90301.1; AAS90302.1; BAG65136.1; CAD38897.1; CAE45835.1; CAE45933.1; EAW81385.1; EAW81388.1; EAW81389.1; EAW81390.1; AAH11793.1; AAH23641.1; AAH27607.1; CAD62593.1; CAD62609.1; CAD66576.1; AAD42873.1

Protein Name

Zinc finger CCCH domain-containing protein 14

Protein Synonyms/Alias

Mammalian suppressor of tau pathology-2; MSUT-2; Renal carcinoma antigen NY-REN-37

Gene Name

ZC3H14

Gene Synonyms/Alias

Created Date

July 27, 2013

Organism

Homo sapiens (Human)

NCBI Taxa ID

9606

Lysine Modification

Position	Peptide	Type	References
160	TRLMSTVKPLREPAP	ubiquitination	[1]
175	SEDVIDIKPEPDDLI	ubiquitination	[1]
283	FFRNNSEKMSMEDEN	ubiquitination	[1]
368	EAQESVTKTTNYSTV	ubiquitination	[1]
378	NYSTVPQKQTLPVAP	ubiquitination	[1]
473	SFILKKPKLSEEVVV	ubiquitination	[1]
489	PNQESGMKTADSLRV	ubiquitination	[1]

Reference

[1] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661]

Functional Description

Binds the polyadenosine RNA oligonucleotides.

Sequence Annotation

ZN_FING 595 620 C3H1-type 1.
ZN_FING 621 640 C3H1-type 2.
ZN_FING 641 656 C3H1-type 3.
ZN_FING 682 699 C3H1-type 4.
ZN_FING 701 719 C3H1-type 5.
MOD_RES 357 357 N6-acetyllysine.
MOD_RES 515 515 Phosphoserine.
MOD_RES 620 620 Phosphoserine.

Keyword

Acetylation; Alternative splicing; Complete proteome; Cytoplasm; Metal-binding; Nucleus; Phosphoprotein; Reference proteome; Repeat; RNA-binding; Zinc; Zinc-finger.

Sequence Source

UniProt (SWISSPROT/TrEMBL); GenBank; EMBL

Protein Length

736 AA

Protein Sequence

MEIGTEISRK IRSAIKGKLQ ELGAYVDEEL PDYIMVMVAN KKSQDQMTED LSLFLGNNTI 60
RFTVWLHGVL DKLRSVTTEP SSLKSSDTNI FDSNVPSNKS NFSRGDERRH EAAVPPLAIP 120
SARPEKRDSR VSTSSQESKT TNVRQTYDDG AATRLMSTVK PLREPAPSED VIDIKPEPDD 180
LIDEDLNFVQ ENPLSQKKPT VTLTYGSSRP SIEIYRPPAS RNADSGVHLN RLQFQQQQNS 240
IHAAKQLDMQ SSWVYETGRL CEPEVLNSLE ETYSPFFRNN SEKMSMEDEN FRKRKLPVVS 300
SVVKVKKFNH DGEEEEEDDD YGSRTGSISS SVSVPAKPER RPSLPPSKQA NKNLILKAIS 360
EAQESVTKTT NYSTVPQKQT LPVAPRTRTS QEELLAEVVQ GQSRTPRISP PIKEEETKGD 420
SVEKNQGTQQ RQLLSRLQID PVMAETLQMS QDYYDMESMV HADTRSFILK KPKLSEEVVV 480
APNQESGMKT ADSLRVLSGH LMQTRDLVQP DKPASPKFIV TLDGVPSPPG YMSDQEEDMC 540
FEGMKPVNQT AASNKGLRGL LHPQQLHLLS RQLEDPNGSF SNAEMSELSV AQKPEKLLER 600
CKYWPACKNG DECAYHHPIS PCKAFPNCKF AEKCLFVHPN CKYDAKCTKP DCPFTHVSRR 660
IPVLSPKPVA PPAPPSSSQL CRYFPACKKM ECPFYHPKHC RFNTQCTRPD CTFYHPTINV 720
PPRHALKWIR PQTSE 735

Gene Ontology

GO:0005737; C:cytoplasm; IDA:HPA.
GO:0016607; C:nuclear speck; IEA:UniProtKB-SubCell.
GO:0005634; C:nucleus; IDA:UniProtKB.
GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
GO:0008270; F:zinc ion binding; IEA:InterPro.

Interpro

IPR000571; Znf_CCCH.

Pfam

SMART

SM00356; ZnF_C3H1

PROSITE

PS50103; ZF_C3H1

PRINTS