| Tag | Content |
|---|
| CPLM ID | CPLM-001558 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Myotubularin-related protein 5 |
Protein Synonyms/Alias | SET-binding factor 1; Sbf1 |
Gene Name | SBF1 |
Gene Synonyms/Alias | MTMR5 |
Created Date | July 27, 2013 |
Organism | Homo sapiens (Human) |
NCBI Taxa ID | 9606 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 401 | EPVIRFHKAAFLGQR | ubiquitination | [1] | | 523 | IVDQAAAKMQGAPPA | ubiquitination | [1] | | 532 | QGAPPAVKAERRTTV | ubiquitination | [1] | | 775 | LLPLDSSKSRLLRER | ubiquitination | [1] | | 836 | FINRFVDKVCTESGV | ubiquitination | [1] |
|
Reference | [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments. Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA. Mol Cell Proteomics. 2013 Mar;12(3):825-31. [ PMID: 23266961] |
Functional Description | Probable pseudophosphatase. Lacks several amino acids in the catalytic pocket which renders it catalytically inactive as a phosphatase. The pocket is however sufficiently preserved to bind phosphorylated substrates, and maybe protect them from phosphatases. Inhibits myoblast differentiation in vitro and induces oncogenic transformation in fibroblasts. According to PubMed:20937701, may function as a guanine nucleotide exchange factor (GEF) activating RAB28. Promotes the exchange of GDP to GTP, converting inactive GDP-bound Rab proteins into their active GTP-bound form. |
Sequence Annotation | DOMAIN 18 86 UDENN.
DOMAIN 128 310 DENN.
DOMAIN 363 432 dDENN.
DOMAIN 880 968 GRAM.
DOMAIN 1120 1596 Myotubularin phosphatase.
DOMAIN 1761 1865 PH.
MOD_RES 1137 1137 Phosphothreonine.
MOD_RES 1749 1749 Phosphothreonine (By similarity). |
Keyword | Alternative splicing; Complete proteome; Guanine-nucleotide releasing factor; Nucleus; Phosphoprotein; Reference proteome. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 1867 AA |
Protein Sequence | MARLADYFVL VAFGPHPRGS GEGQGQILQR FPEKDWEDNP FPQGIELFCQ PSGWQLCPER 60
NPPTFFVAVL TDINSERHYC ACLTFWEPAE PSQETTRVED ATEREEEGDE GGQTHLSPTA 120
PAPSAQLFAP KTLVLVSRLD HTEVFRNSLG LIYAIHVEGL NVCLENVIGN LLTCTVPLAG 180
GSQRTISLGA GDRQVIQTPL ADSLPVSRCS VALLFRQLGI TNVLSLFCAA LTEHKVLFLS 240
RSYQRLADAC RGLLALLFPL RYSFTYVPIL PAQLLEVLST PTPFIIGVNA AFQAETQELL 300
DVIVADLDGG TVTIPECVHI PPLPEPLQSQ THSVLSMVLD PELELADLAF PPPTTSTSSL 360
KMQDKELRAV FLRLFAQLLQ GYRWCLHVVR IHPEPVIRFH KAAFLGQRGL VEDDFLMKVL 420
EGMAFAGFVS ERGVPYRPTD LFDELVAHEV ARMRADENHP QRVLRHVQEL AEQLYKNENP 480
YPAVAMHKVQ RPGESSHLRR VPRPFPRLDE GTVQWIVDQA AAKMQGAPPA VKAERRTTVP 540
SGPPMTAILE RCSGLHVNSA RRLEVVRNCI SYVFEGKMLE AKKLLPAVLR ALKGRAARRC 600
LAQELHLHVQ QNRAVLDHQQ FDFVVRMMNC CLQDCTSLDE HGIAAALLPL VTAFCRKLSP 660
GVTQFAYSCV QEHVVWSTPQ FWEAMFYGDV QTHIRALYLE PTEDLAPAQE VGEAPSQEDE 720
RSALDVASEQ RRLWPTLSRE KQQELVQKEE STVFSQAIHY ANRMSYLLLP LDSSKSRLLR 780
ERAGLGDLES ASNSLVTNSM AGSVAESYDT ESGFEDAETC DVAGAVVRFI NRFVDKVCTE 840
SGVTSDHLKG LHVMVPDIVQ MHIETLEAVQ RESRRLPPIQ KPKLLRPRLL PGEECVLDGL 900
RVYLLPDGRE EGAGGSAGGP ALLPAEGAVF LTTYRVIFTG MPTDPLVGEQ VVVRSFPVAA 960
LTKEKRISVQ TPVDQLLQDG LQLRSCTFQL LKMAFDEEVG SDSAELFRKQ LHKLRYPPDI 1020
RATFAFTLGS AHTPGRPPRV TKDKGPSLRT LSRNLVKNAK KTIGRQHVTR KKYNPPSWEH 1080
RGQPPPEDQE DEISVSEELE PSTLTPSSAL KPSDRMTMSS LVERACCRDY QRLGLGTLSS 1140
SLSRAKSEPF RISPVNRMYA ICRSYPGLLI VPQSVQDNAL QRVSRCYRQN RFPVVCWRSG 1200
RSKAVLLRSG GLHGKGVVGL FKAQNAPSPG QSQADSSSLE QEKYLQAVVS SMPRYADASG 1260
RNTLSGFSSA HMGSHVPSPR ARVTTLSNPM AASASRRTAP RGKWGSVRTS GRSSGLGTDV 1320
GSRLAGRDAL APPQANGGPP DPGFLRPQRA ALYILGDKAQ LKGVRSDPLQ QWELVPIEVF 1380
EARQVKASFK KLLKACVPGC PAAEPSPASF LRSLEDSEWL IQIHKLLQVS VLVVELLDSG 1440
SSVLVGLEDG WDITTQVVSL VQLLSDPFYR TLEGFRLLVE KEWLSFGHRF SHRGAHTLAG 1500
QSSGFTPVFL QFLDCVHQVH LQFPMEFEFS QFYLKFLGYH HVSRRFRTFL LDSDYERIEL 1560
GLLYEEKGER RGQVPCRSVW EYVDRLSKRT PVFHNYMYAP EDAEVLRPYS NVSNLKVWDF 1620
YTEETLAEGP PYDWELAQGP PEPPEEERSD GGAPQSRRRV VWPCYDSCPR AQPDAISRLL 1680
EELQRLETEL GQPAERWKDT WDRVKAAQRL EGRPDGRGTP SSLLVSTAPH HRRSLGVYLQ 1740
EGPVGSTLSL SLDSDQSSGS TTSGSRQAAR RSTSTLYSQF QTAESENRSY EGTLYKKGAF 1800
MKPWKARWFV LDKTKHQLRY YDHRVDTECK GVIDLAEVEA VAPGTPTMGA PKTVDEKAFF 1860
DVKTTRRVYN FCAQDVPSAQ QWVDRIQSCL SDA 1893 |
Gene Ontology | GO:0016021; C:integral to membrane; TAS:UniProtKB. GO:0005634; C:nucleus; IEA:UniProtKB-SubCell. GO:0005543; F:phospholipid binding; IEA:InterPro. GO:0008138; F:protein tyrosine/serine/threonine phosphatase activity; TAS:UniProtKB. GO:0017112; F:Rab guanyl-nucleotide exchange factor activity; IDA:UniProtKB. GO:0006470; P:protein dephosphorylation; TAS:UniProtKB. GO:0007283; P:spermatogenesis; IEA:Compara. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |