CPLM-009557

Genbank Nucleotide ID

Protein Synonyms/Alias

Position	Peptide	Type	References
6	**MSGRGKGGKGLGK	acetylation	[1, 2, 3]
9	SGRGKGGKGLGKGGA	acetylation	[1, 2, 3]
13	KGGKGLGKGGAKRHR	acetylation	[1, 2, 3]
17	GLGKGGAKRHRKVLR	acetylation	[1, 2, 3, 4, 5]

[1] Patterns of histone acetylation.
Thorne AW, Kmiciek D, Mitchelson K, Sautiere P, Crane-Robinson C.
Eur J Biochem. 1990 Nov 13;193(3):701-13. [PMID: 2249688]
[2] Histone H4 from cuttlefish testis is sequentially acetylated. Comparison with acetylation of calf thymus histone H4.
Couppez M, Martin-Ponthieu A, Sautière P.
J Biol Chem. 1987 Feb 25;262(6):2854-60. [PMID: 3818624]
[3] Modification of histones during spermiogenesis in trout: a molecular mechanism for altering histone binding to DNA.
Sung MT, Dixon GH.
Proc Natl Acad Sci U S A. 1970 Nov;67(3):1616-23. [PMID: 5274484]
[4] Calf and pea histone IV. II. The complete amino acid sequence of calf thymus histone IV; presence of epsilon-N-acetyllysine.
DeLange RJ, Fambrough DM, Smith EL, Bonner J.
J Biol Chem. 1969 Jan 25;244(2):319-34. [PMID: 5773298]
[5] Structural analysis of the glycine-rich, arginine-rich histone. 3. Sequence of the amino-terminal half of the molecule containing the modified lysine residues and the total sequence.
Ogawa Y, Quagliarotti G, Jordan J, Taylor CW, Starbuck WC, Busch H.
J Biol Chem. 1969 Aug 25;244(16):4387-92. [PMID: 5817359]

Functional Description

Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.

DNA_BIND 17 21
MOD_RES 2 2 N-acetylserine.
MOD_RES 2 2 Phosphoserine (By similarity).
MOD_RES 4 4 Asymmetric dimethylarginine; by PRMT1;
MOD_RES 4 4 Citrulline; alternate (By similarity).
MOD_RES 4 4 Omega-N-methylarginine; by PRMT1;
MOD_RES 4 4 Symmetric dimethylarginine; by PRMT5 and
MOD_RES 6 6 N6-acetyllysine; alternate (By
MOD_RES 6 6 N6-crotonyl-L-lysine; alternate (By
MOD_RES 9 9 N6-acetyllysine; alternate (By
MOD_RES 9 9 N6-crotonyl-L-lysine; alternate (By
MOD_RES 13 13 N6-acetyllysine; alternate (By
MOD_RES 13 13 N6-crotonyl-L-lysine; alternate (By
MOD_RES 17 17 N6-acetyllysine; alternate.
MOD_RES 17 17 N6-crotonyl-L-lysine; alternate (By
MOD_RES 21 21 N6,N6,N6-trimethyllysine; alternate (By
MOD_RES 21 21 N6,N6-dimethyllysine; alternate.
MOD_RES 21 21 N6-methyllysine; alternate.
MOD_RES 32 32 N6-acetyllysine (By similarity).
MOD_RES 48 48 Phosphoserine; by PAK2 (By similarity).
MOD_RES 52 52 Phosphotyrosine (By similarity).
MOD_RES 89 89 Phosphotyrosine (By similarity).
MOD_RES 92 92 N6-acetyllysine; alternate (By
CROSSLNK 92 92 Glycyl lysine isopeptide (Lys-Gly)

Acetylation; Chromosome; Citrullination; Complete proteome; Direct protein sequencing; DNA-binding; Isopeptide bond; Methylation; Nucleosome core; Nucleus; Phosphoprotein; Reference proteome; Ubl conjugation.

UniProt (SWISSPROT/TrEMBL); GenBank; EMBL

GO:0015629; C:actin cytoskeleton; IEA:Compara.
GO:0005730; C:nucleolus; IEA:Compara.
GO:0005654; C:nucleoplasm; TAS:Reactome.
GO:0000786; C:nucleosome; IEA:UniProtKB-KW.
GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
GO:0045653; P:negative regulation of megakaryocyte differentiation; IEA:Compara.
GO:0006334; P:nucleosome assembly; IEA:InterPro.

IPR009072; Histone-fold.
IPR007125; Histone_core_D.
IPR001951; Histone_H4.
IPR019809; Histone_H4_CS.