CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-014136
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Zinc finger MYM-type protein 4 
Protein Synonyms/Alias
 Zinc finger protein 262 
Gene Name
 ZMYM4 
Gene Synonyms/Alias
 KIAA0425; ZNF262 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
140KLKKDFPKQFDQVSVubiquitination[1, 2]
169SKETFSGKEKNRDLTacetylation[3]
195KDLDSRLKSSFFDKAubiquitination[3]
232SSYPFANKESIGSELubiquitination[3, 4]
250FASNIRIKEEPLDDEsumoylation[5]
273QGLLDKIKDEPDNAQsumoylation[5]
289YSHGQQQKTQEGELKubiquitination[6]
474CSDACFSKFRSANNLubiquitination[4]
761EGCKLLYKHDLAKRWubiquitination[4]
1127QEADSELKQFSKGETubiquitination[1, 2, 4]
1152DSFDPLNKGQGIQARubiquitination[4]
1179QPRRRGRKKSIVAVEubiquitination[4]
1180PRRRGRKKSIVAVEPubiquitination[4]
1221WKNWVQWKNAKEEQGubiquitination[4]
1231KEEQGDLKCGGVEQAubiquitination[4]
1341RFMIELTKLLKIWEPubiquitination[1, 2]
1419RTLKYSTKMTYLRFFubiquitination[4]
1479LYEFYLSKCSESVKQubiquitination[4]
1536EVHEELAKAKSEDSDubiquitination[4]
Reference
 [1] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [2] hCKSAAP_UbSite: improved prediction of human ubiquitination sites by exploiting amino acid pattern and properties.
 Chen Z, Zhou Y, Song J, Zhang Z.
 Biochim Biophys Acta. 2013 Aug;1834(8):1461-7. [PMID: 23603789]
 [3] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302]
 [4] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [5] Site-specific identification of SUMO-2 targets in cells reveals an inverted SUMOylation motif and a hydrophobic cluster SUMOylation motif.
 Matic I, Schimmel J, Hendriks IA, van Santen MA, van de Rijke F, van Dam H, Gnad F, Mann M, Vertegaal AC.
 Mol Cell. 2010 Aug 27;39(4):641-52. [PMID: 20797634]
 [6] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983
Functional Description
 Plays a role in the regulation of cell morphology and cytoskeletal organization. 
Sequence Annotation
 ZN_FING 362 402 MYM-type 1.
 ZN_FING 414 457 MYM-type 2.
 ZN_FING 464 499 MYM-type 3.
 ZN_FING 510 544 MYM-type 4.
 ZN_FING 554 592 MYM-type 5.
 ZN_FING 600 631 MYM-type 6.
 ZN_FING 708 742 MYM-type 7.
 ZN_FING 749 788 MYM-type 8.
 ZN_FING 795 829 MYM-type 9.
 MOD_RES 2 2 N-acetylalanine.
 MOD_RES 107 107 Phosphothreonine.
 MOD_RES 110 110 Phosphoserine.
 MOD_RES 122 122 Phosphoserine.
 MOD_RES 162 162 Phosphoserine.
 MOD_RES 1030 1030 Phosphoserine.
 MOD_RES 1181 1181 Phosphoserine.
 MOD_RES 1256 1256 Phosphoserine.
 MOD_RES 1539 1539 Phosphoserine.
 MOD_RES 1542 1542 Phosphoserine.
 MOD_RES 1547 1547 Phosphoserine.  
Keyword
 Acetylation; Alternative splicing; Complete proteome; Metal-binding; Phosphoprotein; Polymorphism; Reference proteome; Repeat; Zinc; Zinc-finger. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 1548 AA 
Protein Sequence
MAEREVESGP RKRFEQKSGA VFDEIVENCG GIMDTEMSED IDHNLTPTLD SMSYGMPNQT 60
GSENSLLDED DYFLNSGDLA GIPVVGSDNE DEQDFSSKDN LVSSIHTDDS LEVERRVTQH 120
ESDNENEIQI QNKLKKDFPK QFDQVSVFKS IRKDFSLVRE NSKETFSGKE KNRDLTYERE 180
KRLDKPHKDL DSRLKSSFFD KAANQVEETL HTHLPQTPET NFRDSSYPFA NKESIGSELG 240
NSFASNIRIK EEPLDDEYDK AMAPQQGLLD KIKDEPDNAQ EYSHGQQQKT QEGELKISAV 300
FSVSGSPLAP QLTTGFQPSL ASSGMNKMLP SVPATAVRVS CSGCKKILQK GQTAYQRKGS 360
TQLFCSTLCL TGYTVPPARP PPPLTKKTCS SCSKDILNPK DVISAQFENT TTSKDFCSQS 420
CLSTYELKKK PIVTINTNSI STKCSMCQKN AVIRHEVNYQ NVVHKLCSDA CFSKFRSANN 480
LTMNCCENCG GYCYSGSGQC HMLQIEGQSK KFCSSSCITA YKQKSAKITP CALCKSLRSS 540
AEMIENTNSL GKTELFCSVN CLSAYRVKMV TSAGVQVQCN SCKTSAIPQY HLAMSDGSIR 600
NFCSYSCVVA FQNLFNKPTG MNSSVVPLSQ GQVIVSIPTG STVSAGGGST SAVSPTSISS 660
SAAAGLQRLA AQSQHVGFAR SVVKLKCQHC NRLFATKPEL LDYKGKMFQF CGKNCSDEYK 720
KINNVMAMCE YCKIEKIVKE TVRFSGADKS FCSEGCKLLY KHDLAKRWGN HCKMCSYCLQ 780
TSPKLVQNNL GGKVEEFCCE ECMSKYTVLF YQMAKCDACK RQGKLSESLK WRGEMKHFCN 840
LLCILMFCNQ QSVCDPPSQN NAANISMVQA ASAGPPSLRK DSTPVIANVV SLASAPAAQP 900
TVNSNSVLQG AVPTVTAKII GDASTQTDAL KLPPSQPPRL LKNKALLCKP ITQTKATSCK 960
PHTQNKECQT EDTPSQPQII VVPVPVPVFV PIPLHLYTQY APVPFGIPVP MPVPMLIPSS 1020
MDSEDKVTES IEDIKEKLPT HPFEADLLEM AEMIAEDEEK KTLSQGESQT SEHELFLDTK 1080
IFEKDQGSTY SGDLESEAVS TPHSWEEELN HYALKSNAVQ EADSELKQFS KGETEQDLEA 1140
DFPSDSFDPL NKGQGIQARS RTRRRHRDGF PQPRRRGRKK SIVAVEPRSL IQGAFQGCSV 1200
SGMTLKYMYG VNAWKNWVQW KNAKEEQGDL KCGGVEQASS SPRSDPLGST QDHALSQESS 1260
EPGCRVRSIK LKEDILSCTF AELSLGLCQF IQEVRRPNGE KYDPDSILYL CLGIQQYLFE 1320
NGRIDNIFTE PYSRFMIELT KLLKIWEPTI LPNGYMFSRI EEEHLWECKQ LGAYSPIVLL 1380
NTLLFFNTKY FQLKNVTEHL KLSFAHVMRR TRTLKYSTKM TYLRFFPPLQ KQESEPDKLT 1440
VGKRKRNEDD EVPVGVEMAE NTDNPLRCPV RLYEFYLSKC SESVKQRNDV FYLQPERSCV 1500
PNSPMWYSTF PIDPGTLDTM LTRILMVREV HEELAKAKSE DSDVELSD 1548 
Gene Ontology
 GO:0003677; F:DNA binding; TAS:ProtInc.
 GO:0008270; F:zinc ion binding; IEA:InterPro.
 GO:0007010; P:cytoskeleton organization; IMP:UniProtKB.
 GO:0007275; P:multicellular organismal development; TAS:ProtInc.
 GO:0022604; P:regulation of cell morphogenesis; IMP:UniProtKB. 
Interpro
 IPR021893; DUF3504.
 IPR011017; TRASH_dom.
 IPR010507; Znf_MYM. 
Pfam
 PF12012; DUF3504
 PF06467; zf-FCS 
SMART
 SM00746; TRASH 
PROSITE
  
PRINTS