CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-005116
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Proteasome subunit alpha type-7-1 
Protein Synonyms/Alias
 PROS-Dm28.1; Proteasome 28 kDa subunit 1 
Gene Name
 Pros28.1 
Gene Synonyms/Alias
 PROS-28.1; CG3422 
Created Date
 July 27, 2013 
Organism
 Drosophila melanogaster (Fruit fly) 
NCBI Taxa ID
 7227 
Lysine Modification
Position
Peptide
Type
References
50VVLGVEKKSVAQLQEacetylation[1]
Reference
 [1] Proteome-wide mapping of the Drosophila acetylome demonstrates a high degree of conservation of lysine acetylation.
 Weinert BT, Wagner SA, Horn H, Henriksen P, Liu WR, Olsen JV, Jensen LJ, Choudhary C.
 Sci Signal. 2011 Jul 26;4(183):ra48. [PMID: 21791702
Functional Description
 The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity. 
Sequence Annotation
 MOD_RES 177 177 Phosphoserine.  
Keyword
 Complete proteome; Cytoplasm; Hydrolase; Nucleus; Phosphoprotein; Protease; Proteasome; Reference proteome; Threonine protease. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 249 AA 
Protein Sequence
MSSRYDRAVT IFSPDGHLLQ VEYAQEAVRK GSTAVGVRGA NCVVLGVEKK SVAQLQEDRK 60
VRKICMLDNH VVMAFAGLTA DARIMINRAQ VECQSHRLNV EDPVTLEYIT RFIAQLKQKY 120
TQSNGRRPFG ISCLIGGFDA DGSAHLFQTE PSGIFYEYKA NATGRSAKVV REFFEKSYRE 180
EEVANEHGAV KLAIRALLEV AQSGQNNLEV AIMENGKPLK MLDTDVITDY VKIIEKEKEE 240
ELEKKKQKK 249 
Gene Ontology
 GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
 GO:0005875; C:microtubule associated complex; IDA:FlyBase.
 GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
 GO:0005839; C:proteasome core complex; IDA:FlyBase.
 GO:0019773; C:proteasome core complex, alpha-subunit complex; IEA:InterPro.
 GO:0004298; F:threonine-type endopeptidase activity; IEA:UniProtKB-KW.
 GO:0043161; P:proteasomal ubiquitin-dependent protein catabolic process; IC:FlyBase.
 GO:0006974; P:response to DNA damage stimulus; IMP:FlyBase. 
Interpro
 IPR000426; Proteasome_asu_N.
 IPR023332; Proteasome_suA-type.
 IPR001353; Proteasome_sua/b. 
Pfam
 PF00227; Proteasome
 PF10584; Proteasome_A_N 
SMART
 SM00948; Proteasome_A_N 
PROSITE
 PS00388; PROTEASOME_A_1
 PS51475; PROTEASOME_A_2 
PRINTS