CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-038533
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Peptidyl-glycine alpha-amidating monooxygenase 
Protein Synonyms/Alias
  
Gene Name
 Pam 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
816VLGRLRGKGSSGLNLubiquitination[1]
Reference
 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 873 AA 
Protein Sequence
MAGRARSRLL LLLGLLALQS SCLAFRSPLS VFKRFKETTR SFSNECLGTT RPITPIDSSD 60
FTLDIRMPGV TPKESDTYFC MSMRLPVDEE AFVIDFKPRA SMDTVHHMLL FGCNMPSSTG 120
SYWFCDEGTC TDKANILYAW ARNAPPTRLP KGVGFRVGGE TGSKYFVLQV HYGDISAFRD 180
NHKDCSGVSL HLTRVPQPLI AGMYLMMSVN TVIPPGEKVV NSDISCHYKM YPMHVFAYRV 240
HTHHLGKVVS GYRVRNGQWT LIGRQSPQLP QAFYPVEHPV DVAFGDILAA RCVFTGEGRT 300
EATHIGGTSS DEMCNLYIMY YMEAKHAVSF MTCTQNVAPD MFRTIPEEAN IPIPVKSDMV 360
MIHGHHKETE NKEKSALIQQ PKQGEEEAFE QDFHVEEALE WPGVYLLPGQ VSGVALDSKN 420
NLVIFHRGDH VWDGNSFDSK FVYQQRGLGP IEEDTILVID PNKAEILQSS GKNLFYLPHG 480
LSIDTDGNYW VTDVALHQVF KLEPRSKEGP LLVLGRSMQP GSDQNHFCQP TDVAVEPSTG 540
AVFVSDGYCN SRIVQFSPSG KFITQWGEES SGSSPKPGQF SVPHSLALVP HLNQLCVADR 600
ENGRIQCFKT DTKEFVREIK HASFGRNVFA ISYIPGFLFA VNGKPYFGDQ EPVQGFVMNF 660
SSGEIIDVFK PVRKHFDMPH DIVASEDGTV YIGDAHTNTV WKFTLTESRL EVEHRSVKKA 720
GIEVPEIKEA EAVVEPKVKN KPTSSELQKM QEKKKLIKDP GSGVPVVLIT TLLVIPVVVL 780
LAIAMFIRWK KSRAFGDHDR KLESSSGRVL GRLRGKGSSG LNLGNFFASR KGYSRKGFDR 840
VSTEGSDQEK DEDDGSESEE EYSAPLPTPA PSS 873 
Gene Ontology
 GO:0005829; C:cytosol; TAS:MGI.
 GO:0005887; C:integral to plasma membrane; TAS:MGI.
 GO:0005507; F:copper ion binding; IEA:InterPro.
 GO:0004504; F:peptidylglycine monooxygenase activity; TAS:MGI.
 GO:0006518; P:peptide metabolic process; TAS:MGI. 
Interpro
 IPR011042; 6-blade_b-propeller_TolB-like.
 IPR014784; Cu2_ascorb_mOase-like_C.
 IPR020611; Cu2_ascorb_mOase_CS-1.
 IPR014783; Cu2_ascorb_mOase_CS-2.
 IPR000323; Cu2_ascorb_mOase_N.
 IPR001258; NHL_repeat.
 IPR013017; NHL_repeat_subgr.
 IPR000720; Pep_amidat_mOase.
 IPR008977; PHM/PNGase_F_dom. 
Pfam
 PF01082; Cu2_monooxygen
 PF01436; NHL 
SMART
  
PROSITE
 PS00084; CU2_MONOOXYGENASE_1
 PS00085; CU2_MONOOXYGENASE_2
 PS51125; NHL 
PRINTS
 PR00790; PAMONOXGNASE.