UniProt Accession

 PEX2_HUMAN; P28328; Q567S6; Q9BW41 

Genbank Protein ID

 M86852; AF133826; M85038; AC090810; BC000661; BC005375; BC093043 

Genbank Nucleotide ID

 AAC12785.1; AAF97687.1; AAA60141.1; AAH05375.1; AAH93043.1 

Protein Name

 Peroxisome biogenesis factor 2 

Protein Synonyms/Alias

 35 kDa peroxisomal membrane protein; Peroxin-2; Peroxisomal membrane protein 3; Peroxisome assembly factor 1; PAF-1; RING finger protein 72 

Gene Name

 PEX2 

Gene Synonyms/Alias

 PAF1; PMP3; PMP35; PXMP3; RNF72 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
84	GQSVLNIKYKNDFSP	acetylation	[1]
86	SVLNIKYKNDFSPNL	ubiquitination	[2]
219	NVQKLKAKLSSWCIP	ubiquitination	[2]

Reference

 [1] Lysine acetylation targets protein complexes and co-regulates major cellular functions.
 Choudhary C, Kumar C, Gnad F, Nielsen ML, Rehman M, Walther TC, Olsen JV, Mann M.
 Science. 2009 Aug 14;325(5942):834-40. [PMID: 19608861]
 [2] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961] 

Functional Description

 Somewhat implicated in the biogenesis of peroxisomes. 

Sequence Annotation

 ZN_FING 244 284 RING-type.
 MOD_RES 84 84 N6-acetyllysine.  

Keyword

 Acetylation; Complete proteome; Disease mutation; Membrane; Metal-binding; Peroxisome; Peroxisome biogenesis; Peroxisome biogenesis disorder; Reference proteome; Transmembrane; Transmembrane helix; Zellweger syndrome; Zinc; Zinc-finger. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 305 AA 

Protein Sequence

Gene Ontology

 GO:0016593; C:Cdc73/Paf1 complex; IDA:UniProtKB.
 GO:0005779; C:integral to peroxisomal membrane; IMP:UniProtKB.
 GO:0008270; F:zinc ion binding; IEA:InterPro.
 GO:0006699; P:bile acid biosynthetic process; IEA:Compara.
 GO:0042632; P:cholesterol homeostasis; IEA:Compara.
 GO:0006635; P:fatty acid beta-oxidation; IMP:UniProtKB.
 GO:0050680; P:negative regulation of epithelial cell proliferation; IMP:UniProtKB.
 GO:0048147; P:negative regulation of fibroblast proliferation; IMP:UniProtKB.
 GO:0000122; P:negative regulation of transcription from RNA polymerase II promoter; IMP:UniProtKB.
 GO:0001764; P:neuron migration; IEA:Compara.
 GO:0031648; P:protein destabilization; IMP:UniProtKB.
 GO:0016558; P:protein import into peroxisome matrix; IMP:UniProtKB.
 GO:0045540; P:regulation of cholesterol biosynthetic process; IEA:Compara.
 GO:0000038; P:very long-chain fatty acid metabolic process; IMP:UniProtKB. 

Interpro

 IPR006845; Pex_N.
 IPR018957; Znf_C3HC4_RING-type.
 IPR001841; Znf_RING.
 IPR013083; Znf_RING/FYVE/PHD.
 IPR017907; Znf_RING_CS. 

Pfam

 PF04757; Pex2_Pex12
 PF00097; zf-C3HC4 

SMART

 SM00184; RING 

PROSITE

 PS00518; ZF_RING_1
 PS50089; ZF_RING_2 

PRINTS