CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-017783
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Nuclear pore complex protein Nup133 
Protein Synonyms/Alias
 133 kDa nucleoporin; Nucleoporin Nup133 
Gene Name
 Nup133 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
786RQHGIILKMVYPQADacetylation[1, 2, 3, 4]
1109KILQKLIKDGIQLSEubiquitination[5]
Reference
 [1] Quantitative acetylome analysis reveals the roles of SIRT1 in regulating diverse substrates and cellular pathways.
 Chen Y, Zhao W, Yang JS, Cheng Z, Luo H, Lu Z, Tan M, Gu W, Zhao Y.
 Mol Cell Proteomics. 2012 Oct;11(10):1048-62. [PMID: 22826441]
 [2] Proteomic investigations of lysine acetylation identify diverse substrates of mitochondrial deacetylase sirt3.
 Sol EM, Wagner SA, Weinert BT, Kumar A, Kim HS, Deng CX, Choudhary C.
 PLoS One. 2012;7(12):e50545. [PMID: 23236377]
 [3] SIRT5-Mediated Lysine Desuccinylation Impacts Diverse Metabolic Pathways.
 Park J, Chen Y, Tishkoff DX, Peng C, Tan M, Dai L, Xie Z, Zhang Y, Zwaans BM, Skinner ME, Lombard DB, Zhao Y.
 Mol Cell. 2013 Jun 27;50(6):919-30. [PMID: 23806337]
 [4] Quantification of mitochondrial acetylation dynamics highlights prominent sites of metabolic regulation.
 Still AJ, Floyd BJ, Hebert AS, Bingman CA, Carson JJ, Gunderson DR, Dolan BK, Grimsrud PA, Dittenhafer-Reed KE, Stapleton DS, Keller MP, Westphall MS, Denu JM, Attie AD, Coon JJ, Pagliarini DJ.
 J Biol Chem. 2013 Jul 17;. [PMID: 23864654]
 [5] BTB-ZF factors recruit the E3 ligase cullin 3 to regulate lymphoid effector programs.
 Mathew R, Seiler MP, Scanlon ST, Mao AP, Constantinides MG, Bertozzi-Villa C, Singer JD, Bendelac A.
 Nature. 2012 Nov 22;491(7425):618-21. [PMID: 23086144] 
Functional Description
 Involved in poly(A)+ RNA transport (By similarity). 
Sequence Annotation
 MOD_RES 1 1 N-acetylmethionine (By similarity).
 MOD_RES 7 7 Phosphoserine (By similarity).
 MOD_RES 27 27 Phosphoserine (By similarity).
 MOD_RES 28 28 Phosphothreonine (By similarity).
 MOD_RES 40 40 Phosphoserine (By similarity).
 MOD_RES 44 44 Phosphoserine (By similarity).
 MOD_RES 49 49 Phosphoserine (By similarity).
 MOD_RES 479 479 Phosphoserine (By similarity).
 MOD_RES 500 500 Phosphoserine.  
Keyword
 Acetylation; Centromere; Chromosome; Complete proteome; Kinetochore; mRNA transport; Nuclear pore complex; Nucleus; Phosphoprotein; Protein transport; Reference proteome; Translocation; Transport. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 1155 AA 
Protein Sequence
MFPSVSSPRT PGPGTRRGPL VGIGPTSTPR ASRRGLSLGS AVNSPVLFSP AGRRSSVSSR 60
GTPTRIFPHH SISESVNYDV RVFGSSLPVK IMEALTMAEA DEQLSVHVDE GGWACLVCTE 120
KLLIWKIAVS PVTKLSVCKE LQLPPSDFHG SADLVALSYA ATSGEVHSVQ AVSVMVATKE 180
GSIRYWPSLA REDTYSDTCV DLGGEKMCRF LTAVQGGSFI LSSVGSQLVR LIPESSGKIH 240
QHVLPQGQGM LSGIGRRVSS LFGILSPTSD LMLASVLWDR GGSSFYTLTS SNISKWELDD 300
SSEKQVHSWD VHRTLKESIT DAVWGSESNY EAIKEGVNIQ YLDLKQNCDG LLILAAAWHL 360
GDSPCLVYYS VITVEDNGNQ MSDAVTVEVT QYNPPFQSED LIACRLMVPN FSSQMTYLYM 420
ENAVFVCSTG TGKFSLPQEK IVFDTQGDGI LGAGSCAGVP ILFSRNSGLV SVTPRENVSL 480
LAEDLEESLT SSVGGRGSES MVFETTTKNE TVAHEDKTKL LKAAFLQYCR KDLGRAQIMA 540
DELFSSHTDL DSDPELDKAV TQISVDLIDD YPASDPRWAE SVPQEAPGLS NTSLIILHQL 600
EDKMKAHCLL VDFLHQVGLF RRLSSYPIRG TPMSTRLLLC EHAEKLSAAI TLKNHHSRLP 660
DLVNSAILLA LNKRECEVPN SLTPADVFFR EVSQVDTICE CLLEHEEQVL REVALVSQEW 720
AEVAIDVNTV LKDMLQAATH YRLNKSSMYS QEEVLGKEPE YVPWTATSGP SGIRTAVMRQ 780
HGIILKMVYP QADSKLRNVV MEQLVALIDC FLDSYVSQLK SLEKSSDQER YSSLEVEYLQ 840
KRSELLSPLL TLGQYPWAAS LAEKYCDFDI LVQMCEQTDN QARLQRYMTQ FADQNFSDFL 900
FRWYLEKGKR GKLLSQPISQ HGQLANFLQA HEHLSWLHEI NSQELEKAHT TLLGLANMET 960
RYFAKKKTLL GLSKLAALAS DISEDRLQEK IEAMAEQERF LLHQETLPEQ LLTERQLSLS 1020
AMPVLTAPQL ISLYICDENR RANEYDFKKA LDLLEYIDEE EDVSIDDLKL EILCRALQRD 1080
DWSGSDGKDD PIEVSKDSVF VKILQKLIKD GIQLSEYLPE VTDLLRAEQL GSLKSNSYFE 1140
FVLKANYEYY VQGQM 1155 
Gene Ontology
 GO:0000940; C:condensed chromosome outer kinetochore; IEA:Compara.
 GO:0031080; C:nuclear pore outer ring; ISS:UniProtKB.
 GO:0005487; F:nucleocytoplasmic transporter activity; ISS:UniProtKB.
 GO:0006406; P:mRNA export from nucleus; ISS:UniProtKB.
 GO:0006999; P:nuclear pore organization; IEA:Compara.
 GO:0048339; P:paraxial mesoderm development; IMP:MGI.
 GO:0015031; P:protein transport; IEA:UniProtKB-KW. 
Interpro
 IPR007187; Nucleoporin_Nup133/Nup155_C.
 IPR014908; Nucleoporin_Nup133/Nup155_N.
 IPR015943; WD40/YVTN_repeat-like_dom. 
Pfam
 PF03177; Nucleoporin_C
 PF08801; Nucleoporin_N 
SMART
  
PROSITE
  
PRINTS