CPLM-022900

CPLM 1.0 - Compendium of Protein Lysine Modification

Tag

Content

CPLM ID

CPLM-022900

UniProt Accession

KCNN3_HUMAN; Q9UGI6; B1ANX0; O43517; Q86VF9; Q8WXG7

Genbank Protein ID

AF031815; AJ251016; AF438203; AF336797; AY138900; AL390204; AL606500; AL954342; AL390204; AL606500; AL954342; AL606500; AL390204; AL954342; AL606500; AL390204; AL954342; AL954342; AL390204; AL606500; AL954342; AL390204; AL606500; CH471121; CH471121; BC042147

Genbank Nucleotide ID

AAC26099.1; CAB61331.1; AAL40801.1; AAK15345.1; AAN46636.1; CAH71150.1; CAH71150.1; CAH71150.1; CAH71151.1; CAH71151.1; CAH71151.1; CAH71910.1; CAH71910.1; CAH71910.1; CAH71911.1; CAH71911.1; CAH71911.1; CAH72738.1; CAH72738.1; CAH72738.1; CAH72739.1; CAH72739.1; CAH72739.1; EAW53180.1; EAW53182.1; AAH42147.1

Protein Name

Small conductance calcium-activated potassium channel protein 3

Protein Synonyms/Alias

SK3; SKCa 3; SKCa3; KCa2.3

Gene Name

KCNN3

Gene Synonyms/Alias

Created Date

July 27, 2013

Organism

Homo sapiens (Human)

NCBI Taxa ID

9606

Lysine Modification

Position	Peptide	Type	References
447	RSIGALNKINFNTRF	ubiquitination	[1]

Reference

[1] Systematic and quantitative assessment of the ubiquitin-modified proteome.
Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]

Functional Description

Forms a voltage-independent potassium channel activated by intracellular calcium. Activation is followed by membrane hyperpolarization. Thought to regulate neuronal excitability by contributing to the slow component of synaptic afterhyperpolarization. The channel is blocked by apamin.

Sequence Annotation

REGION 566 642 Calmodulin-binding (By similarity).

Keyword

Alternative splicing; Calmodulin-binding; Complete proteome; Ion channel; Ion transport; Membrane; Polymorphism; Reference proteome; Transmembrane; Transmembrane helix; Transport.

Sequence Source

UniProt (SWISSPROT/TrEMBL); GenBank; EMBL

Protein Length

736 AA

Protein Sequence

MDTSGHFHDS GVGDLDEDPK CPCPSSGDEQ QQQQQQQQQQ QPPPPAPPAA PQQPLGPSLQ 60
PQPPQLQQQQ QQQQQQQQQQ QQQQQPPHPL SQLAQLQSQP VHPGLLHSSP TAFRAPPSSN 120
STAILHPSSR QGSQLNLNDH LLGHSPSSTA TSGPGGGSRH RQASPLVHRR DSNPFTEIAM 180
SSCKYSGGVM KPLSRLSASR RNLIEAETEG QPLQLFSPSN PPEIVISSRE DNHAHQTLLH 240
HPNATHNHQH AGTTASSTTF PKANKRKNQN IGYKLGHRRA LFEKRKRLSD YALIFGMFGI 300
VVMVIETELS WGLYSKDSMF SLALKCLISL STIILLGLII AYHTREVQLF VIDNGADDWR 360
IAMTYERILY ISLEMLVCAI HPIPGEYKFF WTARLAFSYT PSRAEADVDI ILSIPMFLRL 420
YLIARVMLLH SKLFTDASSR SIGALNKINF NTRFVMKTLM TICPGTVLLV FSISLWIIAA 480
WTVRVCERYH DQQDVTSNFL GAMWLISITF LSIGYGDMVP HTYCGKGVCL LTGIMGAGCT 540
ALVVAVVARK LELTKAEKHV HNFMMDTQLT KRIKNAAANV LRETWLIYKH TKLLKKIDHA 600
KVRKHQRKFL QAIHQLRSVK MEQRKLSDQA NTLVDLSKMQ NVMYDLITEL NDRSEDLEKQ 660
IGSLESKLEH LTASFNSLPL LIADTLRQQQ QQLLSAIIEA RGVSVAVGTT HTPISDSPIG 720
VSSTSFPTPY TSSSSC 736

Gene Ontology

GO:0005737; C:cytoplasm; IEA:Compara.
GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
GO:0005886; C:plasma membrane; TAS:Reactome.
GO:0016286; F:small conductance calcium-activated potassium channel activity; IEA:InterPro.
GO:0007268; P:synaptic transmission; TAS:Reactome.

Interpro

IPR004178; CaM-bd_dom.
IPR013099; Ion_trans_2.
IPR015449; K_chnl_Ca-activ_SK.

Pfam

PF02888; CaMBD
PF07885; Ion_trans_2
PF03530; SK_channel

SMART

SM01053; CaMBD

PROSITE

PRINTS

PR01451; SKCHANNEL.