CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-015935
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Tetratricopeptide repeat protein 21B 
Protein Synonyms/Alias
 TPR repeat protein 21B 
Gene Name
 TTC21B 
Gene Synonyms/Alias
 KIAA1992; Nbla10696 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
308RSQLILQKIQTLLERubiquitination[1, 2]
575IKAQSQKKMGEIADAubiquitination[2]
693YFIEAREKMADIYLKubiquitination[2]
705YLKHRKDKMLYITCFubiquitination[2]
761KDGTLASKMGKALIKubiquitination[2]
846KVYSKMEKLGDAITAubiquitination[2]
880PDAVPAQKHLAAEICubiquitination[2]
902VAQRDYEKAIKFYREubiquitination[2]
905RDYEKAIKFYREALVubiquitination[2]
1020EKRNSRAKLEPGFQYubiquitination[2]
1134NYCLMATKQKSNVEQubiquitination[2]
1185NQLKRIAKMNWNAIDubiquitination[2]
1221DMAEDLLKRCLRHNRubiquitination[2]
1278KLAFNYLKAKRYVDSubiquitination[2]
Reference
 [1] Global identification of modular cullin-RING ligase substrates.
 Emanuele MJ, Elia AE, Xu Q, Thoma CR, Izhar L, Leng Y, Guo A, Chen YN, Rush J, Hsu PW, Yen HC, Elledge SJ.
 Cell. 2011 Oct 14;147(2):459-74. [PMID: 21963094]
 [2] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961] 
Functional Description
 Component of the IFT complex A (IFT-A), a complex required for retrograde ciliary transport. Negatively modulates the SHH signal transduction (By similarity). 
Sequence Annotation
 REPEAT 108 141 TPR 1.
 REPEAT 145 178 TPR 2.
 REPEAT 180 211 TPR 3.
 REPEAT 285 323 TPR 4.
 REPEAT 324 357 TPR 5.
 REPEAT 492 525 TPR 6.
 REPEAT 563 596 TPR 7.
 REPEAT 617 650 TPR 8.
 REPEAT 722 755 TPR 9.
 REPEAT 757 789 TPR 10.
 REPEAT 791 822 TPR 11.
 REPEAT 831 864 TPR 12.
 REPEAT 884 917 TPR 13.
 REPEAT 919 951 TPR 14.
 REPEAT 952 985 TPR 15.
 REPEAT 1023 1056 TPR 16.
 REPEAT 1197 1230 TPR 17.
 REPEAT 1232 1264 TPR 18.
 REPEAT 1266 1299 TPR 19.  
Keyword
 Alternative splicing; Bardet-Biedl syndrome; Cell projection; Ciliopathy; Cilium; Complete proteome; Cytoplasm; Cytoskeleton; Disease mutation; Joubert syndrome; Meckel syndrome; Mental retardation; Nephronophthisis; Obesity; Polymorphism; Reference proteome; Repeat; TPR repeat. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 1316 AA 
Protein Sequence
MDSQELKTLI NYYCQERYFH HVLLVASEGI KRYGSDPVFR FYHAYGTLME GKTQEALREF 60
EAIKNKQDVS LCSLLALIYA HKMSPNPDRE AILESDARVK EQRKGAGEKA LYHAGLFLWH 120
IGRHDKAREY IDRMIKISDG SKQGHVLKAW LDITRGKEPY TKKALKYFEE GLQDGNDTFA 180
LLGKAQCLEM RQNYSGALET VNQIIVNFPS FLPAFVKKMK LQLALQDWDQ TVETAQRLLL 240
QDSQNVEALR MQALYYVCRE GDIEKASTKL ENLGNTLDAM EPQNAQLFYN ITLAFSRTCG 300
RSQLILQKIQ TLLERAFSLN PQQSEFATEL GYQMILQGRV KEALKWYKTA MTLDETSVSA 360
LVGFIQCQLI EGQLQDADQQ LEFLNEIQQS IGKSAELIYL HAVLAMKKNK RQEEVINLLN 420
DVLDTHFSQL EGLPLGIQYF EKLNPDFLLE IVMEYLSFCP MQPASPGQPL CPLLRRCISV 480
LETVVRTVPG LLQTVFLIAK VKYLSGDIEA AFNNLQHCLE HNPSYADAHL LLAQVYLSQE 540
KVKLCSQSLE LCLSYDFKVR DYPLYHLIKA QSQKKMGEIA DAIKTLHMAM SLPGMKRIGA 600
STKSKDRKTE VDTSHRLSIF LELIDVHRLN GEQHEATKVL QDAIHEFSGT SEEVRVTIAN 660
ADLALAQGDI ERALSILQNV TAEQPYFIEA REKMADIYLK HRKDKMLYIT CFREIAERMA 720
NPRSFLLLGD AYMNILEPEE AIVAYEQALN QNPKDGTLAS KMGKALIKTH NYSMAITYYE 780
AALKTGQKNY LCYDLAELLL KLKWYDKAEK VLQHALAHEP VNELSALMED GRCQVLLAKV 840
YSKMEKLGDA ITALQQAREL QARVLKRVQM EQPDAVPAQK HLAAEICAEI AKHSVAQRDY 900
EKAIKFYREA LVHCETDNKI MLELARLYLA QDDPDSCLRQ CALLLQSDQD NEAATMMMAD 960
LMFRKQDYEQ AVFHLQQLLE RKPDNYMTLS RLIDLLRRCG KLEDVPRFFS MAEKRNSRAK 1020
LEPGFQYCKG LYLWYTGEPN DALRHFNKAR KDRDWGQNAL YNMIEICLNP DNETVGGEVF 1080
ENLDGDLGNS TEKQESVQLA VRTAEKLLKE LKPQTVQGHV QLRIMENYCL MATKQKSNVE 1140
QALNTFTEIA ASEKEHIPAL LGMATAYMIL KQTPRARNQL KRIAKMNWNA IDAEEFEKSW 1200
LLLADIYIQS AKYDMAEDLL KRCLRHNRSC CKAYEYMGYI MEKEQAYTDA ALNYEMAWKY 1260
SNRTNPAVGY KLAFNYLKAK RYVDSIDICH QVLEAHPTYP KIRKDILDKA RASLRP 1316 
Gene Ontology
 GO:0035085; C:cilium axoneme; IEA:UniProtKB-SubCell.
 GO:0005856; C:cytoskeleton; IEA:UniProtKB-KW.
 GO:0030991; C:intraflagellar transport particle A; IDA:UniProtKB.
 GO:0060271; P:cilium morphogenesis; IEA:Compara.
 GO:0042073; P:intraflagellar transport; IEA:Compara.
 GO:0007224; P:smoothened signaling pathway; IEA:Compara. 
Interpro
 IPR001440; TPR-1.
 IPR013026; TPR-contain_dom.
 IPR011990; TPR-like_helical.
 IPR013105; TPR_2.
 IPR019734; TPR_repeat. 
Pfam
 PF00515; TPR_1
 PF07719; TPR_2
 PF13174; TPR_6 
SMART
 SM00028; TPR 
PROSITE
 PS50005; TPR
 PS50293; TPR_REGION 
PRINTS