UniProt Accession

 E7ET07_HUMAN; E7ET07 

Genbank Protein ID

 AC004537 

Genbank Nucleotide ID

  

Protein Name

 Inhibitor of growth protein 3 

Protein Synonyms/Alias

  

Gene Name

 ING3 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
37	EFFMNAKKNKPEWRE	ubiquitination	[1]
51	EEQMASIKKDYYKAL	ubiquitination	[1]
64	ALEDADEKVQLANQI	ubiquitination	[1, 2]
149	TTDHIPEKKFKSEAL	acetylation	[2]
152	HIPEKKFKSEALLST	ubiquitination	[2]
166	TLTSDASKENTLGCR	acetylation	[2, 3]
166	TLTSDASKENTLGCR	ubiquitination	[2]
249	NNDFQLGKEFSMARE	acetylation	[2, 3]
249	NNDFQLGKEFSMARE	ubiquitination	[1, 2]
385	LTEAPKGKWYCPQCT	ubiquitination	[1]
396	PQCTAAMKRRGSRHK	ubiquitination	[1]

Reference

 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302]
 [3] Proteomic investigations of lysine acetylation identify diverse substrates of mitochondrial deacetylase sirt3.
 Sol EM, Wagner SA, Weinert BT, Kumar A, Kim HS, Deng CX, Choudhary C.
 PLoS One. 2012;7(12):e50545. [PMID: 23236377] 

Functional Description

  

Sequence Annotation

  

Keyword

 Complete proteome; Metal-binding; Reference proteome; Zinc; Zinc-finger. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 403 AA 

Protein Sequence

Gene Ontology

 GO:0008270; F:zinc ion binding; IEA:InterPro. 

Interpro

 IPR024610; ING_N.
 IPR019786; Zinc_finger_PHD-type_CS.
 IPR011011; Znf_FYVE_PHD.
 IPR001965; Znf_PHD.
 IPR019787; Znf_PHD-finger.
 IPR013083; Znf_RING/FYVE/PHD. 

Pfam

 PF12998; ING
 PF00628; PHD 

SMART

 SM00249; PHD 

PROSITE

 PS01359; ZF_PHD_1
 PS50016; ZF_PHD_2 

PRINTS