CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-008035
UniProt Accession
Genbank Protein ID
 M81475 
Genbank Nucleotide ID
Protein Name
 Serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform 
Protein Synonyms/Alias
 CAM-PRP catalytic subunit; Calcineurin, testis-specific catalytic subunit; Calmodulin-dependent calcineurin A subunit gamma isoform 
Gene Name
 Ppp3cc 
Gene Synonyms/Alias
 Calnc 
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
386EGATTGRKEVIKNKIacetylation[1]
Reference
 [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405] 
Functional Description
 Calcium-dependent, calmodulin-stimulated protein phosphatase. This subunit may have a role in the calmodulin activation of calcineurin. 
Sequence Annotation
 ACT_SITE 147 147 Proton donor (By similarity).
 METAL 86 86 Iron (By similarity).
 METAL 88 88 Iron (By similarity).
 METAL 114 114 Iron (By similarity).
 METAL 114 114 Zinc (By similarity).
 METAL 146 146 Zinc (By similarity).
 METAL 195 195 Zinc (By similarity).
 METAL 277 277 Zinc (By similarity).  
Keyword
 Calmodulin-binding; Complete proteome; Hydrolase; Iron; Metal-binding; Protein phosphatase; Reference proteome; Zinc. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 513 AA 
Protein Sequence
MSVRRPQFST TERVIKAVPF PPTRRLTLKE VFENGKPKMD LLKNHLVKEG RVEEEVALKI 60
INDGAAILKQ EKTMIEVEAP ITVCGDVHGQ FFDLMKLFEV GGSPSNTRYL FLGDYVDRGY 120
FSIECVLYLW SLKINHPKTL FLLRGNHECR HLTEYFTFKQ ECRIKYSEMV YDACMHTFDC 180
LPLAALLNQQ FLCVHGGMSP EITCLEDIRK LDRFSEPPAF GPVCDLLWSD PLEDYGSEKT 240
LEHYTHNTVR GCSYFFSYPA VCEFLQNNSL LSIIRAHEAQ DAGYRMYRKN QATGFPSLIT 300
IFSAPNYLDV YNNKAAVLKY ENNVMNIRQF NCSPHPYWLP NFMDVFTWSL PFVGEKVTEM 360
LVNILNICSD EEMNVTDEEG ATTGRKEVIK NKIRAIGKMA RVFTVLREES ENVLTLKGLT 420
PTGTLPLGVL SGGKQTIETA KQEAAEEREA IRGFTIAHRI RSFEEARGLD RINERMPPRK 480
EASYHHDAGR MHSHSHPPHP QASRRTDHGK KAL 513 
Gene Ontology
 GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
 GO:0004721; F:phosphoprotein phosphatase activity; IEA:UniProtKB-KW. 
Interpro
 IPR004843; Metallo_PEstase_dom.
 IPR006186; Ser/Thr-sp_prot-phosphatase. 
Pfam
 PF00149; Metallophos 
SMART
 SM00156; PP2Ac 
PROSITE
 PS00125; SER_THR_PHOSPHATASE 
PRINTS
 PR00114; STPHPHTASE.