CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-023376
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 RuvB-like helicase 1 
Protein Synonyms/Alias
 Dpontin; Dpon; Pontin 
Gene Name
 pont 
Gene Synonyms/Alias
 CG4003 
Created Date
 July 27, 2013 
Organism
 Drosophila melanogaster (Fruit fly) 
NCBI Taxa ID
 7227 
Lysine Modification
Position
Peptide
Type
References
2******MKIEEVKSTacetylation[1]
Reference
 [1] Proteome-wide mapping of the Drosophila acetylome demonstrates a high degree of conservation of lysine acetylation.
 Weinert BT, Wagner SA, Horn H, Henriksen P, Liu WR, Olsen JV, Jensen LJ, Choudhary C.
 Sci Signal. 2011 Jul 26;4(183):ra48. [PMID: 21791702] 
Functional Description
 Acts as a transcriptional coactivator in Wg signaling caused by altered arm signaling. Pont and rept interfere antagonistically with nuclear arm signaling function, and are required to enhance or reduce arm activity, respectively. Also an essential cofactor for the normal function of Myc; required for cellular proliferation and growth. 
Sequence Annotation
 NP_BIND 70 77 ATP (By similarity).  
Keyword
 Activator; ATP-binding; Cell cycle; Cell division; Chromatin regulator; Complete proteome; DNA damage; DNA recombination; DNA repair; Helicase; Hydrolase; Nucleotide-binding; Nucleus; Reference proteome; Transcription; Transcription regulation. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 456 AA 
Protein Sequence
MKIEEVKSTV RTQRIAAHSH VKGLGLDEVG AAVHSAAGLV GQKAAREAAG IVVDLIKSKK 60
MAGRALLLAG PPGTGKTAIA LAIAQELGNK VPFCPMVGSE VFSNEIKKTE VLMENFRRSI 120
GLRIRETKEV YEGEVTELTP VETENPMGGY GKTISNVVIG LKTAKGTKQL KLDPSIFDAL 180
QKEKVEVGDV IYIEANSGAV KRQGRSDTFA TEFDLETEEY VPLPKGDVHK KKEVIQDVTL 240
HDLDVANARP QGGQDVLSMM GQLMKPKKTE ITDKLRMEIN KVVNKYIDQG IAELVPGVLF 300
IDEIHMLDLE TFTYLHKSLE SPIAPIVIFA TNRGRCVIRG TTDIVSPHGI PLDLLDRLLI 360
IRTLLYSTAD MEQIIKLRAQ TEGLQLEENA FTRLSEIGTS STLRYAVQLL TPAHQMCKVN 420
GRNQISKDDI EDVHSLFLDA KRSSKHLSEK NNKFML 456 
Gene Ontology
 GO:0035060; C:brahma complex; IDA:FlyBase.
 GO:0031011; C:Ino80 complex; IDA:UniProtKB.
 GO:0005875; C:microtubule associated complex; IDA:FlyBase.
 GO:0035267; C:NuA4 histone acetyltransferase complex; IDA:UniProtKB.
 GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
 GO:0043141; F:ATP-dependent 5'-3' DNA helicase activity; IEA:InterPro.
 GO:0003713; F:transcription coactivator activity; IMP:UniProtKB.
 GO:0051301; P:cell division; IEA:UniProtKB-KW.
 GO:0032508; P:DNA duplex unwinding; IEA:GOC.
 GO:0006310; P:DNA recombination; IEA:UniProtKB-KW.
 GO:0006281; P:DNA repair; IEA:UniProtKB-KW.
 GO:0016573; P:histone acetylation; IDA:UniProtKB.
 GO:0043486; P:histone exchange; IDA:UniProtKB.
 GO:0007095; P:mitotic G2 DNA damage checkpoint; IGI:FlyBase.
 GO:0010628; P:positive regulation of gene expression; IMP:FlyBase.
 GO:0042127; P:regulation of cell proliferation; IMP:UniProtKB.
 GO:0006355; P:regulation of transcription, DNA-dependent; IEA:UniProtKB-KW.
 GO:0030111; P:regulation of Wnt receptor signaling pathway; IMP:UniProtKB.
 GO:0090307; P:spindle assembly involved in mitosis; IMP:FlyBase.
 GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW. 
Interpro
 IPR003593; AAA+_ATPase.
 IPR012340; NA-bd_OB-fold.
 IPR027417; P-loop_NTPase.
 IPR027238; RuvB-like.
 IPR010339; TIP49_C. 
Pfam
 PF06068; TIP49 
SMART
 SM00382; AAA 
PROSITE
  
PRINTS