CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-031990
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Myotubularin related protein 1, isoform CRA_a 
Protein Synonyms/Alias
 Myotubularin-related protein 1; cDNA FLJ56376, highly similar to Myotubularin-related protein 1 (EC 3.1.3.-) 
Gene Name
 MTMR1 
Gene Synonyms/Alias
 hCG_1640369 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
65GVISRVEKIGAQSHGubiquitination[1]
83CGIEIVCKDMRNLRLubiquitination[1]
93RNLRLAYKQEEQSKLubiquitination[1]
143YDPVSEYKRQGLPNEubiquitination[1, 2, 3]
153GLPNESWKISKINSNubiquitination[1]
156NESWKISKINSNYEFubiquitination[1]
184VKDDDLSKVAAFRAKubiquitination[1]
Reference
 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [3] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983] 
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Hydrolase; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 571 AA 
Protein Sequence
MEEAPLFPGE SIKAIVKDVM YICPFMGAVS GTLTVTDFKL YFKNVERDPH FILDVPLGVI 60
SRVEKIGAQS HGDNSCGIEI VCKDMRNLRL AYKQEEQSKL GIFENLNKHA FPLSNGQALF 120
AFSYKEKFPI NGWKVYDPVS EYKRQGLPNE SWKISKINSN YEFCDTYPAI IVVPTSVKDD 180
DLSKVAAFRA KGRVPVLSWI HPESQATITR CSQPLVGPND KRCKEDEKYL QTIMDANAQS 240
HKLIIFDARQ NSVADTNKTK GGGYESESAY PNAELVFLEI HNIHVMRESL RKLKEIVYPS 300
IDEARWLSNV DGTHWLEYIR MLLAGAVRIA DKIESGKTSV VVHCSDGWDR TAQLTSLAML 360
MLDSYYRTIK GFETLVEKEW ISFGHRFALR VGHGNDNHAD ADRSPIFLQF VDCVWQMTRQ 420
FPSAFEFNEL FLITILDHLY SCLFGTFLCN CEQQRFKEDV YTKTISLWSY INSQLDEFSN 480
PFFVNYENHV LYPVASLSHL ELWVNYYVRW NPRMRPQMPI HQNLKELLAV RAELQKRVEG 540
LQREVATRAV SSSSERGSSP SHSATSVHTS V 571 
Gene Ontology
 GO:0005737; C:cytoplasm; IEA:Compara.
 GO:0005886; C:plasma membrane; IEA:Compara.
 GO:0004438; F:phosphatidylinositol-3-phosphatase activity; IEA:Compara.
 GO:0004725; F:protein tyrosine phosphatase activity; IEA:InterPro.
 GO:0035335; P:peptidyl-tyrosine dephosphorylation; IEA:GOC. 
Interpro
 IPR004182; GRAM.
 IPR010569; Myotub-related.
 IPR017906; Myotubularin_phosphatase_dom.
 IPR011993; PH_like_dom.
 IPR000387; Tyr/Dual-sp_Pase.
 IPR016130; Tyr_Pase_AS. 
Pfam
 PF02893; GRAM
 PF06602; Myotub-related 
SMART
 SM00568; GRAM 
PROSITE
 PS51339; PPASE_MYOTUBULARIN
 PS00383; TYR_PHOSPHATASE_1
 PS50056; TYR_PHOSPHATASE_2 
PRINTS