| Tag | Content |
|---|
| CPLM ID | CPLM-022027 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Histone-lysine N-methyltransferase PRDM9 |
Protein Synonyms/Alias | PR domain zinc finger protein 9; PR domain-containing protein 9 |
Gene Name | PRDM9 |
Gene Synonyms/Alias | PFM6 |
Created Date | July 27, 2013 |
Organism | Homo sapiens (Human) |
NCBI Taxa ID | 9606 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 844 | CGRGFRNKSHLLRHQ | acetylation | [1] |
|
Reference | [1] Regulation of cellular metabolism by protein lysine acetylation. Zhao S, Xu W, Jiang W, Yu W, Lin Y, Zhang T, Yao J, Zhou L, Zeng Y, Li H, Li Y, Shi J, An W, Hancock SM, He F, Qin L, Chin J, Yang P, Chen X, Lei Q, Xiong Y, Guan KL. Science. 2010 Feb 19;327(5968):1000-4. [ PMID: 20167786] |
Functional Description | Histone methyltransferase that specifically trimethylates 'Lys-4' of histone H3 during meiotic prophase and is essential for proper meiotic progression. Does not have the ability to mono- and dimethylate 'Lys-4' of histone H3. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation. Plays a central role in the transcriptional activation of genes during early meiotic prophase (By similarity). |
Sequence Annotation | DOMAIN 23 86 KRAB-related.
DOMAIN 244 358 SET.
ZN_FING 388 411 C2H2-type 1.
ZN_FING 524 546 C2H2-type 2; degenerate.
ZN_FING 552 574 C2H2-type 3.
ZN_FING 580 602 C2H2-type 4.
ZN_FING 608 630 C2H2-type 5.
ZN_FING 636 658 C2H2-type 6.
ZN_FING 664 686 C2H2-type 7.
ZN_FING 692 714 C2H2-type 8.
ZN_FING 720 742 C2H2-type 9.
ZN_FING 748 770 C2H2-type 10.
ZN_FING 776 798 C2H2-type 11.
ZN_FING 804 826 C2H2-type 12.
ZN_FING 832 854 C2H2-type 13.
ZN_FING 860 882 C2H2-type 14. |
Keyword | 3D-structure; Activator; Chromatin regulator; Chromosome; Complete proteome; Meiosis; Metal-binding; Methyltransferase; Nucleus; Polymorphism; Reference proteome; Repeat; S-adenosyl-L-methionine; Transcription; Transcription regulation; Transferase; Zinc; Zinc-finger. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 894 AA |
Protein Sequence | MSPEKSQEES PEEDTERTER KPMVKDAFKD ISIYFTKEEW AEMGDWEKTR YRNVKRNYNA 60
LITIGLRATR PAFMCHRRQA IKLQVDDTED SDEEWTPRQQ VKPPWMALRV EQRKHQKGMP 120
KASFSNESSL KELSRTANLL NASGSEQAQK PVSPSGEAST SGQHSRLKLE LRKKETERKM 180
YSLRERKGHA YKEVSEPQDD DYLYCEMCQN FFIDSCAAHG PPTFVKDSAV DKGHPNRSAL 240
SLPPGLRIGP SGIPQAGLGV WNEASDLPLG LHFGPYEGRI TEDEEAANNG YSWLITKGRN 300
CYEYVDGKDK SWANWMRYVN CARDDEEQNL VAFQYHRQIF YRTCRVIRPG CELLVWYGDE 360
YGQELGIKWG SKWKKELMAG REPKPEIHPC PSCCLAFSSQ KFLSQHVERN HSSQNFPGPS 420
ARKLLQPENP CPGDQNQEQQ YPDPHSRNDK TKGQEIKERS KLLNKRTWQR EISRAFSSPP 480
KGQMGSCRVG KRIMEEESRT GQKVNPGNTG KLFVGVGISR IAKVKYGECG QGFSVKSDVI 540
THQRTHTGEK LYVCRECGRG FSWKSHLLIH QRIHTGEKPY VCRECGRGFS WQSVLLTHQR 600
THTGEKPYVC RECGRGFSRQ SVLLTHQRRH TGEKPYVCRE CGRGFSRQSV LLTHQRRHTG 660
EKPYVCRECG RGFSWQSVLL THQRTHTGEK PYVCRECGRG FSWQSVLLTH QRTHTGEKPY 720
VCRECGRGFS NKSHLLRHQR THTGEKPYVC RECGRGFRDK SHLLRHQRTH TGEKPYVCRE 780
CGRGFRDKSN LLSHQRTHTG EKPYVCRECG RGFSNKSHLL RHQRTHTGEK PYVCRECGRG 840
FRNKSHLLRH QRTHTGEKPY VCRECGRGFS DRSSLCYHQR THTGEKPYVC REDE 894 |
Gene Ontology | GO:0005694; C:chromosome; IEA:UniProtKB-SubCell. GO:0005654; C:nucleoplasm; TAS:Reactome. GO:0042800; F:histone methyltransferase activity (H3-K4 specific); IEA:Compara. GO:0010844; F:recombination hotspot binding; IEA:Compara. GO:0043565; F:sequence-specific DNA binding; IEA:Compara. GO:0008270; F:zinc ion binding; IEA:InterPro. GO:0006311; P:meiotic gene conversion; IDA:MGI. GO:0010845; P:positive regulation of reciprocal meiotic recombination; IMP:MGI. GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; IEA:Compara. GO:0007283; P:spermatogenesis; IEA:Compara. GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW. |
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