CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-017186
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Fibrinogen beta chain 
Protein Synonyms/Alias
 Fibrinopeptide B; Fibrinogen beta chain 
Gene Name
 Fgb 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
43HRPVDRRKEEPPSLRubiquitination[1]
237ECEEIIRKGGETSEMubiquitination[1]
254IQPDTSIKPYRVYCDubiquitination[1]
263YRVYCDMKTENGGWTubiquitination[1]
303IATNEDAKKYCGLPGubiquitination[1]
343DWKGDKVKAHYGGFTubiquitination[1]
364KYQVSVNKYKGTAGNubiquitination[1]
416DPRKQCSKEDGGGWWubiquitination[1]
Reference
 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 
Functional Description
 Fibrinogen has a double function: yielding monomers that polymerize into fibrin and acting as a cofactor in platelet aggregation (By similarity). 
Sequence Annotation
 DOMAIN 222 478 Fibrinogen C-terminal.
 REGION 35 37 Beta-chain polymerization, binding distal
 CARBOHYD 384 384 N-linked (GlcNAc...) (Potential).
 DISULFID 213 213 Interchain (with alpha chain) (By
 DISULFID 217 217 Interchain (with gamma chain) (By
 DISULFID 221 306 By similarity.
 DISULFID 231 260 By similarity.
 DISULFID 414 427 By similarity.  
Keyword
 Blood coagulation; Coiled coil; Complete proteome; Disulfide bond; Glycoprotein; Hemostasis; Reference proteome; Secreted; Signal. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 481 AA 
Protein Sequence
MRHLWLLLLL CVFSVQTQAA DDDYDEPTDS LDARGHRPVD RRKEEPPSLR PAPPPISGGG 60
YRARPAKATA NQKKVERRPP DAGGCLHADT DMGVLCPTGC TLQQTLLNQE RPIKSSIAEL 120
NNNIQSVSDT SSVTFQYLTL LKDMWKKKQA QVKENENVIN EYSSILEDQR LYIDETVNDN 180
IPLNLRVLRS ILEDLRSKIQ KLESDISAQM EYCRTPCTVS CNIPVVSGKE CEEIIRKGGE 240
TSEMYLIQPD TSIKPYRVYC DMKTENGGWT VIQNRQDGSV DFGRKWDPYK KGFGNIATNE 300
DAKKYCGLPG EYWLGNDKIS QLTRMGPTEL LIEMEDWKGD KVKAHYGGFT VQNEASKYQV 360
SVNKYKGTAG NALMDGASQL VGENRTMTIH NGMFFSTYDR DNDGWVTTDP RKQCSKEDGG 420
GWWYNRCHAA NPNGRYYWGG LYSWDMSKHG TDDGVVWMNW KGSWYSMRRM SMKIRPFFPQ 480
Q 481 
Gene Ontology
 GO:0072562; C:blood microparticle; IEA:Compara.
 GO:0005938; C:cell cortex; IDA:MGI.
 GO:0009897; C:external side of plasma membrane; IEA:Compara.
 GO:0005577; C:fibrinogen complex; IEA:InterPro.
 GO:0031091; C:platelet alpha granule; IEA:Compara.
 GO:0030168; P:platelet activation; IEA:InterPro.
 GO:0051258; P:protein polymerization; IEA:InterPro.
 GO:0051592; P:response to calcium ion; IEA:Compara.
 GO:0007165; P:signal transduction; IEA:InterPro. 
Interpro
 IPR014716; Fibrinogen_a/b/g_C_1.
 IPR014715; Fibrinogen_a/b/g_C_2.
 IPR002181; Fibrinogen_a/b/g_C_dom.
 IPR012290; Fibrinogen_a/b/g_coil_dom.
 IPR020837; Fibrinogen_CS. 
Pfam
 PF08702; Fib_alpha
 PF00147; Fibrinogen_C 
SMART
 SM00186; FBG 
PROSITE
 PS00514; FIBRINOGEN_C_1
 PS51406; FIBRINOGEN_C_2 
PRINTS