CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-017938
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Protein odd-skipped-related 1 
Protein Synonyms/Alias
  
Gene Name
 OSR1 
Gene Synonyms/Alias
 ODD 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
133ATQEDPAKLGRGEGPubiquitination[1]
160VTKLSPEKKPTRGRLacetylation[2]
161TKLSPEKKPTRGRLPacetylation[2]
172GRLPSKTKKEFVCKFacetylation[2]
Reference
 [1] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [2] Regulation of cellular metabolism by protein lysine acetylation.
 Zhao S, Xu W, Jiang W, Yu W, Lin Y, Zhang T, Yao J, Zhou L, Zeng Y, Li H, Li Y, Shi J, An W, Hancock SM, He F, Qin L, Chin J, Yang P, Chen X, Lei Q, Xiong Y, Guan KL.
 Science. 2010 Feb 19;327(5968):1000-4. [PMID: 20167786] 
Functional Description
 Transcription factor that plays a role in the regulation of embryonic heart and urogenital development (By similarity). 
Sequence Annotation
 ZN_FING 175 197 C2H2-type 1.
 ZN_FING 203 225 C2H2-type 2.
 ZN_FING 231 253 C2H2-type 3.  
Keyword
 Complete proteome; Metal-binding; Nucleus; Reference proteome; Repeat; Transcription; Transcription regulation; Zinc; Zinc-finger. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 266 AA 
Protein Sequence
MGSKTLPAPV PIHPSLQLTN YSFLQAVNGL PTVPSDHLPN LYGFSALHAV HLHQWTLGYP 60
AMHLPRSSFS KVPGTVSSLV DARFQLPAFP WFPHVIQPKP EITAGGSVPA LKTKPRFDFA 120
NLALAATQED PAKLGRGEGP GSPAGGLGAL LDVTKLSPEK KPTRGRLPSK TKKEFVCKFC 180
GRHFTKSYNL LIHERTHTDE RPYTCDICHK AFRRQDHLRD HRYIHSKEKP FKCQECGKGF 240
CQSRTLAVHK TLHSQVKELK TSKIKC 266 
Gene Ontology
 GO:0005730; C:nucleolus; IDA:HPA.
 GO:0003676; F:nucleic acid binding; IEA:InterPro.
 GO:0008270; F:zinc ion binding; IEA:InterPro.
 GO:0071300; P:cellular response to retinoic acid; IEA:Compara.
 GO:0002062; P:chondrocyte differentiation; ISS:BHF-UCL.
 GO:0042733; P:embryonic digit morphogenesis; ISS:BHF-UCL.
 GO:0035115; P:embryonic forelimb morphogenesis; ISS:BHF-UCL.
 GO:0035116; P:embryonic hindlimb morphogenesis; ISS:BHF-UCL.
 GO:0036023; P:embryonic skeletal limb joint morphogenesis; ISS:BHF-UCL.
 GO:0008406; P:gonad development; IEA:Compara.
 GO:0007507; P:heart development; ISS:UniProtKB.
 GO:0048389; P:intermediate mesoderm development; IEA:Compara.
 GO:0072143; P:mesangial cell development; ISS:UniProtKB.
 GO:0072180; P:mesonephric duct morphogenesis; ISS:UniProtKB.
 GO:0090094; P:metanephric cap mesenchymal cell proliferation involved in metanephros development; ISS:UniProtKB.
 GO:0072239; P:metanephric glomerulus vasculature development; ISS:UniProtKB.
 GO:0072259; P:metanephric interstitial cell development; ISS:UniProtKB.
 GO:0072162; P:metanephric mesenchymal cell differentiation; ISS:UniProtKB.
 GO:0072234; P:metanephric nephron tubule development; ISS:UniProtKB.
 GO:0072208; P:metanephric smooth muscle tissue development; ISS:UniProtKB.
 GO:0042474; P:middle ear morphogenesis; ISS:UniProtKB.
 GO:0043066; P:negative regulation of apoptotic process; ISS:UniProtKB.
 GO:0072183; P:negative regulation of nephron tubule epithelial cell differentiation; ISS:UniProtKB.
 GO:0000122; P:negative regulation of transcription from RNA polymerase II promoter; ISS:BHF-UCL.
 GO:0042476; P:odontogenesis; ISS:UniProtKB.
 GO:0060021; P:palate development; ISS:UniProtKB.
 GO:0072268; P:pattern specification involved in metanephros development; ISS:UniProtKB.
 GO:0030501; P:positive regulation of bone mineralization; ISS:BHF-UCL.
 GO:0050679; P:positive regulation of epithelial cell proliferation; ISS:UniProtKB.
 GO:2000543; P:positive regulation of gastrulation; IMP:UniProtKB.
 GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; ISS:BHF-UCL.
 GO:0048793; P:pronephros development; IMP:UniProtKB.
 GO:0072184; P:renal vesicle progenitor cell differentiation; ISS:UniProtKB.
 GO:0072168; P:specification of anterior mesonephric tubule identity; ISS:UniProtKB.
 GO:0072169; P:specification of posterior mesonephric tubule identity; ISS:UniProtKB.
 GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW.
 GO:0072190; P:ureter urothelium development; ISS:UniProtKB.
 GO:0001657; P:ureteric bud development; ISS:UniProtKB. 
Interpro
 IPR007087; Znf_C2H2.
 IPR015880; Znf_C2H2-like.
 IPR013087; Znf_C2H2/integrase_DNA-bd. 
Pfam
  
SMART
 SM00355; ZnF_C2H2 
PROSITE
 PS00028; ZINC_FINGER_C2H2_1
 PS50157; ZINC_FINGER_C2H2_2 
PRINTS