UniProt Accession

 FIBG_RAT; P02680; Q68FY3 

Genbank Protein ID

 J00733; J00734; J00735; X05860; X05861; BC078893; K01337 

Genbank Nucleotide ID

 CAA29289.1; CAA29289.1; AAH78893.1; AAA98626.1 

Protein Name

 Fibrinogen gamma chain 

Protein Synonyms/Alias

  

Gene Name

 Fgg 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Rattus norvegicus (Rat) 

NCBI Taxa ID

 10116 

Lysine Modification

Position	Peptide	Type	References
84	ENRTTEAKELIKAIQ	acetylation	[1]

Reference

 [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405] 

Functional Description

 Fibrinogen has a double function: yielding monomers that polymerize into fibrin and acting as a cofactor in platelet aggregation. 

Sequence Annotation

 DOMAIN 170 416 Fibrinogen C-terminal.
 REGION 400 422 Gamma-chain polymerization, binding amino
 CARBOHYD 78 78 N-linked (GlcNAc...) (Potential).
 DISULFID 34 34 Interchain (with gamma chain) (By
 DISULFID 35 35 Interchain (with gamma chain) (By
 DISULFID 45 45 Interchain (with beta chain) (By
 DISULFID 49 49 Interchain (with alpha chain) (By
 DISULFID 161 161 Interchain (with beta chain) (By
 DISULFID 165 165 Interchain (with gamma chain) (By
 DISULFID 179 208 By similarity.
 DISULFID 352 365 By similarity.
 CROSSLNK 424 424 Isoglutamyl lysine isopeptide (Gln-Lys)
 CROSSLNK 432 432 Isoglutamyl lysine isopeptide (Lys-Gln)  

Keyword

 Alternative splicing; Blood coagulation; Calcium; Coiled coil; Complete proteome; Direct protein sequencing; Disulfide bond; Glycoprotein; Hemostasis; Isopeptide bond; Metal-binding; Reference proteome; Secreted; Signal. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 445 AA 

Protein Sequence

Gene Ontology

 GO:0072562; C:blood microparticle; IDA:RGD.
 GO:0005938; C:cell cortex; IEA:Compara.
 GO:0005737; C:cytoplasm; IDA:RGD.
 GO:0009897; C:external side of plasma membrane; IEA:Compara.
 GO:0005577; C:fibrinogen complex; IEA:InterPro.
 GO:0031091; C:platelet alpha granule; IEA:Compara.
 GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
 GO:0006954; P:inflammatory response; TAS:RGD.
 GO:0030168; P:platelet activation; IEA:InterPro.
 GO:0051258; P:protein polymerization; IEA:InterPro.
 GO:0051592; P:response to calcium ion; IEA:Compara.
 GO:0007165; P:signal transduction; IEA:InterPro. 

Interpro

 IPR014716; Fibrinogen_a/b/g_C_1.
 IPR014715; Fibrinogen_a/b/g_C_2.
 IPR002181; Fibrinogen_a/b/g_C_dom.
 IPR012290; Fibrinogen_a/b/g_coil_dom.
 IPR020837; Fibrinogen_CS. 

Pfam

 PF08702; Fib_alpha
 PF00147; Fibrinogen_C 

SMART

 SM00186; FBG 

PROSITE

 PS00514; FIBRINOGEN_C_1
 PS51406; FIBRINOGEN_C_2 

PRINTS