UniProt Accession

 CENPS_HUMAN; Q8N2Z9; Q8NFE5; Q8NFG5 

Genbank Protein ID

 AF516753; AF521016; AL139424; AL354956; AL354956; AL139424; AL139424; AL354956; AL354956; AL139424; AL139424; AL354956; AL354956; AL139424; BC029430 

Genbank Nucleotide ID

 AAM61954.1; AAM70482.1; CAI95756.1; CAI95756.1; CAI19200.1; CAI19200.1; CAI95757.1; CAI95757.1; CAI19201.1; CAI19201.1; CAI95755.1; CAI95755.1; CAI19199.1; CAI19199.1; AAH29430.1 

Protein Name

 Centromere protein S 

Protein Synonyms/Alias

 CENP-S; Apoptosis-inducing TAF9-like domain-containing protein 1; FANCM-interacting histone fold protein 1; Fanconi anemia-associated polypeptide of 16 kDa 

Gene Name

 APITD1 

Gene Synonyms/Alias

 CENPS; FAAP16; MHF1 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
83	TINTEDVKLLARRSN	ubiquitination	[1]

Reference

 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961] 

Functional Description

 DNA-binding component of the FA core complex involved in DNA damage repair and genome maintenance. Required for optimal chromatin association of the FA core complex. Required for efficient damage-induced monoubiquitination and focus formation of FANCD2. Stabilizes FAAD24, FANCM and STRA13/CENPX in the FA core complex. Plays a role in DNA interstrand cross-linking (ICL) repair and in recovery of replication forks stalled by topoisomerase I-DNA cleavage intermediates induced by camptothecin. Component of the heterotetrameric CENP-T-W-S-X complex that binds and supercoils DNA, and plays an important role in kinetochore assembly. Component of the APITD1/CENPS complex that is essential for the stable assembly of the outer kinetochore. Plays an important role in mitotic progression and chromosome segregation. Component of the CENPA-CAD (nucleosome distal) complex, a complex recruited to centromeres which is involved in assembly of kinetochore proteins, mitotic progression and chromosome segregation. 

Sequence Annotation

  

Keyword

 3D-structure; Alternative splicing; Cell cycle; Cell division; Centromere; Chromosome; Complete proteome; DNA damage; DNA repair; DNA-binding; Fanconi anemia; Kinetochore; Mitosis; Nucleus; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 138 AA 

Protein Sequence

Gene Ontology

 GO:0000777; C:condensed chromosome kinetochore; IEA:UniProtKB-SubCell.
 GO:0005829; C:cytosol; TAS:Reactome.
 GO:0071821; C:FANCM-MHF complex; IDA:UniProtKB.
 GO:0043240; C:Fanconi anaemia nuclear complex; IDA:UniProtKB.
 GO:0003682; F:chromatin binding; IDA:UniProtKB.
 GO:0003677; F:DNA binding; IDA:UniProtKB.
 GO:0051301; P:cell division; IEA:UniProtKB-KW.
 GO:0006281; P:DNA repair; IDA:UniProtKB.
 GO:0007067; P:mitosis; IEA:UniProtKB-KW.
 GO:0000278; P:mitotic cell cycle; TAS:Reactome.
 GO:0031398; P:positive regulation of protein ubiquitination; TAS:UniProtKB.
 GO:0031297; P:replication fork processing; IMP:UniProtKB.
 GO:0000712; P:resolution of meiotic recombination intermediates; IMP:UniProtKB. 

Interpro

 IPR009072; Histone-fold.
 IPR003162; TFIID-31. 

Pfam

 PF02291; TFIID-31kDa 

SMART

  

PROSITE

  

PRINTS