CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-033347
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Eukaryotic translation initiation factor 4 gamma 1 
Protein Synonyms/Alias
  
Gene Name
 EIF4G1 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
885RLLTTIGKDLDFEKAubiquitination[1]
891GKDLDFEKAKPRMDQacetylation[2, 3, 4]
893DLDFEKAKPRMDQYFubiquitination[1]
Reference
 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] Proteomic investigations reveal a role for RNA processing factor THRAP3 in the DNA damage response.
 Beli P, Lukashchuk N, Wagner SA, Weinert BT, Olsen JV, Baskcomb L, Mann M, Jackson SP, Choudhary C.
 Mol Cell. 2012 Apr 27;46(2):212-25. [PMID: 22424773]
 [3] Proteomic investigations of lysine acetylation identify diverse substrates of mitochondrial deacetylase sirt3.
 Sol EM, Wagner SA, Weinert BT, Kumar A, Kim HS, Deng CX, Choudhary C.
 PLoS One. 2012;7(12):e50545. [PMID: 23236377]
 [4] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302] 
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 903 AA 
Protein Sequence
MNKAPQSTGP PPAPSPGLPQ PAFPPGQTAP VVFSTPQATQ MNTPSQPRQG RSTYVVPTQQ 60
YPVQPGAPGF YPGASPTEFG TYAGAYYPAQ GVQQFPTGVA PTPVLMNQPP QIAPKRERKT 120
IRIRDPNQGG KDITEEIMSG ARTASTPTPP QTGGGLEPQA NGETPQVAVI VRPDDRSQGA 180
IIADRPGLPG PEHSPSESQP SSPSPTPSPS PVLEPGSEPN LAVLSIPGDT MTTIQMSVEE 240
STPISRETGE PYRLSPEPTP LAEPILEVEV TLSKPVPESE FSSSPLQAPT PLASHTVEIH 300
EPNGMVPSED LEPEVESSPE LAPPPACPSE SPVPIAPTAQ PEELLNGAPS PPAVDLSPVS 360
EPEEQAKEVT ASMAPPTIPS ATPATAPSAT SPAQEEEMEE EEEEEEGEAG EAGEAESEKG 420
GEELLPPEST PIPANLSQNL EAAAATQVAV SVPKRRRKIK ELNKKEAVGD LLDAFKEANP 480
AVPEVENQPP AGSNPGPESE GSGVPPRPEE ADETWDSKED KIHNAENIQP GEQKYEYKSD 540
QWKPLNLEEK KRYDREFLLG FQFIFASMQK PEGLPHISDV VLDKANKTPL RPLDPTRLQG 600
INCGPDFTPS FANLGRTTLS TRGPPRGGPG GELPRGPAGL GPRRSQQGPR KEPRKIIATV 660
LMTEDIKLNK AEKAWKPSSK RTAADKDRGE EDADGSKTQD LFRRVRSILN KLTPQMFQQL 720
MKQVTQLAID TEERLKGVID LIFEKAISEP NFSVAYANMC RCLMALKVPT TEKPTVTVNF 780
RKLLLNRCQK EFEKDKDDDE VFEKKQKEMD EAATAEERGR LKEELEEARD IARRRSLGNI 840
KFIGELFKLK MLTEAIMHDC VVKLLKNHDE ESLECLCRLL TTIGKDLDFE KAKPRMDQYF 900
NQM 903 
Gene Ontology
 GO:0003677; F:DNA binding; IEA:InterPro.
 GO:0003723; F:RNA binding; IEA:InterPro.
 GO:0016070; P:RNA metabolic process; IEA:InterPro. 
Interpro
 IPR016024; ARM-type_fold.
 IPR016021; MIF4-like_typ_1/2/3.
 IPR003890; MIF4G-like_typ-3. 
Pfam
 PF02854; MIF4G 
SMART
 SM00543; MIF4G 
PROSITE
  
PRINTS