CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-023495
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Solute carrier family 23 member 2 
Protein Synonyms/Alias
 Na(+)/L-ascorbic acid transporter 2; Sodium-dependent vitamin C transporter 2 
Gene Name
 Slc23a2 
Gene Synonyms/Alias
 Svct2 
Created Date
 July 27, 2013 
Organism
 Rattus norvegicus (Rat) 
NCBI Taxa ID
 10116 
Lysine Modification
Position
Peptide
Type
References
350YARTDARKGVLLVAPacetylation[1]
Reference
 [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405] 
Functional Description
 Sodium/ascorbate cotransporter. Mediates electrogenic uptake of vitamin C, with a stoichiometry of 2 Na(+) for each ascorbate. 
Sequence Annotation
 MOD_RES 77 77 Phosphoserine (By similarity).
 MOD_RES 78 78 Phosphothreonine (By similarity).
 MOD_RES 80 80 Phosphoserine (By similarity).
 MOD_RES 646 646 Phosphothreonine (By similarity).
 CARBOHYD 187 187 N-linked (GlcNAc...) (Potential).
 CARBOHYD 195 195 N-linked (GlcNAc...) (Potential).  
Keyword
 Cell membrane; Complete proteome; Glycoprotein; Ion transport; Membrane; Phosphoprotein; Reference proteome; Sodium; Sodium transport; Symport; Transmembrane; Transmembrane helix; Transport. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 647 AA 
Protein Sequence
MMGVGKNTSK SVEVGGSTEG KYEEEAKRPD FFTLPVVING GATSSGEQDN EDTELMAIYT 60
TENGIAEKSS LAETLDSTGS LDPQRSDMIY TIEDVPPWYL CIFLGLQHYL TCFSGTIAVP 120
FLLADAMCVG DDQWATSQLI GTIFFCVGIT TLLQTTFGCR LPLFQASAFA FLAPARAILS 180
LDKWKCNTTE ITVANGTAEL LEHIWHPRIQ EIQGAIIMSS LIEVVIGLLG LPGALLRYIG 240
PLTITPTVAL IGLSGFQAAG ERAGKHWGIA MLTIFLVLLF SQYARNVKFP LPIYKSKKGW 300
TAYKLQLFKM FPIILAILVS WLLCFIFTVT DVFPSNSTDY GYYARTDARK GVLLVAPWFK 360
VPYPFQWGMP TVSAAGVIGM LSAVVASIIE SIGDYYACAR LSCAPPPPIH AINRGIFVEG 420
LSCVLDGVFG TGNGSTSSSP NIGVLGITKV GSRRVIQYGA ALMLGLGMIG KFSALFASLP 480
DPVLGALFCT LFGMITAVGL SNLQFIDLNS SRNLFVLGFS IFFGLVLPSY LRQNPLVTGI 540
TGIDQVLNVL LTTAMFVGGC VAFILDNTIP GTPEERGIKK WKKGVSKGNK SLDGMESYNL 600
PFGMNIIKKY RCFSYLPISP TFAGYTWKGF GKSENRRSSD KDSQATV 647 
Gene Ontology
 GO:0016324; C:apical plasma membrane; IEA:Compara.
 GO:0009925; C:basal plasma membrane; IDA:UniProtKB.
 GO:0005737; C:cytoplasm; IDA:UniProtKB.
 GO:0005887; C:integral to plasma membrane; IDA:RGD.
 GO:0008520; F:L-ascorbate:sodium symporter activity; IMP:RGD.
 GO:0015229; F:L-ascorbic acid transporter activity; IDA:UniProtKB.
 GO:0070890; F:sodium-dependent L-ascorbate transmembrane transporter activity; IEA:Compara.
 GO:0019852; P:L-ascorbic acid metabolic process; IMP:RGD.
 GO:0015882; P:L-ascorbic acid transport; IDA:UniProtKB.
 GO:0006979; P:response to oxidative stress; IEP:RGD.
 GO:0070904; P:transepithelial L-ascorbic acid transport; IEA:Compara. 
Interpro
 IPR006042; Xan_ur_permease.
 IPR006043; Xant/urac/vitC. 
Pfam
 PF00860; Xan_ur_permease 
SMART
  
PROSITE
 PS01116; XANTH_URACIL_PERMASE 
PRINTS