UniProt Accession

 PLCD3_HUMAN; Q8N3E9; Q8TEC1; Q8TF37; Q96FL6 

Genbank Protein ID

 AK074240; BC010668; BC072384; AL834392; AB075844 

Genbank Nucleotide ID

 BAB85029.1; AAH10668.2; AAH72384.1; CAD39054.2; BAB85550.1 

Protein Name

 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-3 

Protein Synonyms/Alias

 Phosphoinositide phospholipase C-delta-3; Phospholipase C-delta-3; PLC-delta-3 

Gene Name

 PLCD3 

Gene Synonyms/Alias

 KIAA1964 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
759	TLPLSSLKQGYRHIH	ubiquitination	[1]

Reference

 [1] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983] 

Functional Description

 Hydrolyzes the phosphatidylinositol 4,5-bisphosphate (PIP2) to generate 2 second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). DAG mediates the activation of protein kinase C (PKC), while IP3 releases Ca(2+) from intracellular stores. Essential for trophoblast and placental development. May participate in cytokinesis by hydrolyzing PIP2 at the cleavage furrow. 

Sequence Annotation

 DOMAIN 63 172 PH.
 DOMAIN 182 217 EF-hand 1.
 DOMAIN 218 253 EF-hand 2.
 DOMAIN 250 285 EF-hand 3.
 DOMAIN 337 482 PI-PLC X-box.
 DOMAIN 528 644 PI-PLC Y-box.
 DOMAIN 647 752 C2.
 REGION 73 101 Substrate binding (By similarity).
 ACT_SITE 352 352 By similarity.
 ACT_SITE 397 397 By similarity.
 METAL 353 353 Calcium 1; catalytic (By similarity).
 METAL 382 382 Calcium 1; catalytic (By similarity).
 METAL 384 384 Calcium 1; catalytic (By similarity).
 METAL 431 431 Calcium 1; catalytic (By similarity).
 METAL 683 683 Calcium 2; via carbonyl oxygen (By
 METAL 685 685 Calcium 2 (By similarity).
 METAL 709 709 Calcium 2 (By similarity).
 METAL 738 738 Calcium 3 (By similarity).
 METAL 739 739 Calcium 3; via carbonyl oxygen (By
 METAL 740 740 Calcium 3 (By similarity).
 BINDING 480 480 Substrate (By similarity).
 BINDING 482 482 Substrate (By similarity).
 BINDING 557 557 Substrate (By similarity).
 BINDING 584 584 Substrate (By similarity).
 MOD_RES 105 105 Phosphoserine.
 MOD_RES 496 496 Phosphoserine (By similarity).  

Keyword

 Calcium; Complete proteome; Cytoplasm; Hydrolase; Lipid degradation; Lipid metabolism; Membrane; Metal-binding; Phosphoprotein; Polymorphism; Reference proteome; Repeat; Transducer. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 789 AA 

Protein Sequence

Gene Ontology

 GO:0032154; C:cleavage furrow; IEA:UniProtKB-SubCell.
 GO:0005829; C:cytosol; IEA:Compara.
 GO:0005886; C:plasma membrane; TAS:Reactome.
 GO:0005509; F:calcium ion binding; IEA:InterPro.
 GO:0004435; F:phosphatidylinositol phospholipase C activity; IEA:EC.
 GO:0005543; F:phospholipid binding; IEA:InterPro.
 GO:0004871; F:signal transducer activity; IEA:UniProtKB-KW.
 GO:0001525; P:angiogenesis; IEA:Compara.
 GO:0043647; P:inositol phosphate metabolic process; TAS:Reactome.
 GO:0035556; P:intracellular signal transduction; IEA:InterPro.
 GO:0060716; P:labyrinthine layer blood vessel development; IEA:Compara.
 GO:0016042; P:lipid catabolic process; IEA:UniProtKB-KW.
 GO:0042127; P:regulation of cell proliferation; IEA:Compara. 

Interpro

 IPR000008; C2_Ca-dep.
 IPR008973; C2_Ca/lipid-bd_dom_CaLB.
 IPR018029; C2_membr_targeting.
 IPR011992; EF-hand-like_dom.
 IPR018247; EF_Hand_1_Ca_BS.
 IPR011993; PH_like_dom.
 IPR001192; Pinositol_PLipase_C.
 IPR017946; PLC-like_Pdiesterase_TIM-brl.
 IPR001849; Pleckstrin_homology.
 IPR015359; PLipase_C_EF-hand-like.
 IPR000909; PLipase_C_PInositol-sp_X_dom.
 IPR001711; PLipase_C_Pinositol-sp_Y. 

Pfam

 PF00168; C2
 PF09279; efhand_like
 PF00388; PI-PLC-X
 PF00387; PI-PLC-Y 

SMART

 SM00239; C2
 SM00233; PH
 SM00148; PLCXc
 SM00149; PLCYc 

PROSITE

 PS50004; C2
 PS00018; EF_HAND_1
 PS50222; EF_HAND_2
 PS50003; PH_DOMAIN
 PS50007; PIPLC_X_DOMAIN
 PS50008; PIPLC_Y_DOMAIN 

PRINTS

 PR00390; PHPHLIPASEC.