CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-011745
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Probable palmitoyltransferase AKR2 
Protein Synonyms/Alias
 Ankyrin repeat-containing protein AKR2 
Gene Name
 AKR2 
Gene Synonyms/Alias
 YOR034C; OR26.25 
Created Date
 July 27, 2013 
Organism
 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) 
NCBI Taxa ID
 559292 
Lysine Modification
Position
Peptide
Type
References
256FYERNNQKQDCFDLAubiquitination[1]
Reference
 [1] Global analysis of phosphorylation and ubiquitylation cross-talk in protein degradation.
 Swaney DL, Beltrao P, Starita L, Guo A, Rush J, Fields S, Krogan NJ, VillĂ©n J.
 Nat Methods. 2013 Jul;10(7):676-82. [PMID: 23749301
Functional Description
 May be involved in constitutive endocytosis of a-factor receptor STE3. 
Sequence Annotation
 REPEAT 49 79 ANK 1.
 REPEAT 83 112 ANK 2.
 REPEAT 117 146 ANK 3.
 REPEAT 150 183 ANK 4.
 REPEAT 189 218 ANK 5.
 REPEAT 222 251 ANK 6.
 ZN_FING 446 496 DHHC-type.
 ACT_SITE 476 476 S-palmitoyl cysteine intermediate (By
 CARBOHYD 534 534 N-linked (GlcNAc...) (Potential).  
Keyword
 Acyltransferase; ANK repeat; Complete proteome; Glycoprotein; Membrane; Metal-binding; Reference proteome; Repeat; Transferase; Transmembrane; Transmembrane helix; Zinc; Zinc-finger. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 749 AA 
Protein Sequence
MTSMSIIDDE NVKKTSNGAA VVTDVAQHAV SDSDNNKAQL LGDGSNTEYV VDIFIEAAKD 60
GDLKVVKDVV ESGAVDINND RIDELSGLHW ACINNRFSVA KFLLLRGANP NQAAGPGGAT 120
ALHWAARYGN IYIVDLLLKH GADPTLKDEQ GLNIMHFSVY SSNILLVVYV LYFVVNNNDN 180
VDIDSKDNNN RTPLLWAAYQ GDFLTVELLL KFGSTVAWTD NRGFNALHCA LVGGDQRVIC 240
DLILSGANFY ERNNQKQDCF DLAEGMGTKS LFEQALQHHG YDRLGNQKDK LFKKSSHAQF 300
TIFLSPFLLM VYIYLISLVL SPVLAIMLSL LVTVVMVNTL KKFVLPCLPR KNTYKVSLTR 360
TPFFSGLFLS TFCFLIYIWT KKLYPYSVSD YTMKNVQFLV TSFLTVVLFL RLVRSDPGCL 420
KTDDSLTSIQ ETIKQLIDLG KFDRENFCVE TLERKPLRSK YSFFSGALVA RYDHYCPWIY 480
NDVGLKNHKL FVFFAVTVQY HMFLFMWLCL AYFKKTNYIY EQVEEYARCA LLKNETLCKG 540
SNYDPSTFFL FIWISVNFIW LGAMLIVQFF QILKGITTPE LFILIKEEHK AKFINLIPFE 600
NSIYTSESKG VEDSDMIPEG PSATTITHTI SIDGLEPRNR RRAILSACFS MMGINQWLVT 660
IKEIVGITHI LHGQVPQQHH SSLLRSFLVT NHWKTNLTDF WLNSDVTAPL WQRFFYSSDT 720
SKAMLGGTEV DYYELYEYPA REGEVLRPN 749 
Gene Ontology
 GO:0005794; C:Golgi apparatus; IDA:SGD.
 GO:0016021; C:integral to membrane; ISM:SGD.
 GO:0016409; F:palmitoyltransferase activity; ISS:SGD.
 GO:0008270; F:zinc ion binding; IEA:InterPro.
 GO:0006897; P:endocytosis; ISS:SGD.
 GO:0018345; P:protein palmitoylation; ISS:SGD. 
Interpro
 IPR002110; Ankyrin_rpt.
 IPR020683; Ankyrin_rpt-contain_dom.
 IPR001594; Znf_DHHC_palmitoyltrfase. 
Pfam
 PF00023; Ank
 PF01529; zf-DHHC 
SMART
 SM00248; ANK 
PROSITE
 PS50297; ANK_REP_REGION
 PS50088; ANK_REPEAT
 PS50216; ZF_DHHC 
PRINTS