CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-023653
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Protein strawberry notch homolog 2 
Protein Synonyms/Alias
  
Gene Name
 SBNO2 
Gene Synonyms/Alias
 KIAA0963 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
337VHALSKIKYGDTTTSubiquitination[1]
410AVLDLQNKLPLARVVubiquitination[1]
457EFLHAIEKRGVGAMEubiquitination[1]
715LERVERLKQDLLDKVubiquitination[1]
894TESRDLSKYNFENKYubiquitination[1]
900SKYNFENKYGTRALHubiquitination[1]
939PTFFRDMKQGLLSVGubiquitination[1]
961NGCLDVEKDCSITKFubiquitination[1]
967EKDCSITKFLNRILGubiquitination[1]
1095GQFFTVYKPNIGRQSubiquitination[1]
1153CRLAQEGKDCLQGLRubiquitination[1]
1229RLMDADVKRRQAPALubiquitination[1]
Reference
 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961] 
Functional Description
 Seems to have transcriptional repression activity in macrophages. 
Sequence Annotation
  
Keyword
 Alternative splicing; Complete proteome; Reference proteome; Repressor; Transcription; Transcription regulation. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 1366 AA 
Protein Sequence
MLAVGPAMDR DYPQHEPPPA GSLLYSPPPL QSAMLHCPYW NTFSLPPYPA FSSDSRPFMS 60
SASFLGSQPC PDTSYAPVAT ASSLPPKTCD FAQDSSYFED FSNISIFSSS VDSLSDIVDT 120
PDFLPADSLN QVSTIWDDNP APSTHDKLFQ LSRPFAGFED FLPSHSTPLL VSYQEQSVQS 180
QPEEEDEAEE EEAEELGHTE TYADYVPSKS KIGKQHPDRV VETSTLSSVP PPDITYTLAL 240
PSDSGALSAL QLEAITYACQ QHEVLLPSGQ RAGFLIGDGA GVGKGRTVAG VILENHLRGR 300
KKALWFSVSN DLKYDAERDL RDIEATGIAV HALSKIKYGD TTTSEGVLFA TYSALIGESQ 360
AGGQHRTRLR QILDWCGEAF EGVIVFDECH KAKNAGSTKM GKAVLDLQNK LPLARVVYAS 420
ATGASEPRNM IYMSRLGIWG EGTPFRNFEE FLHAIEKRGV GAMEIVAMDM KVSGMYIARQ 480
LSFSGVTFRI EEIPLAPAFE CVYNRAALLW AEALNVFQQA ADWIGLESRK SLWGQFWSAH 540
QRFFKYLCIA AKVRRLVELA REELARDKCV VIGLQSTGEA RTREVLGEND GHLNCFVSAA 600
EGVFLSLIQK HFPSTKRKRD RGAGSKRKRR PRGRGAKAPR LACETAGVIR ISDDSSTESD 660
PGLDSDFNSS PESLVDDDVV IVDAVGLPSD DRGPLCLLQR DPHGPGVLER VERLKQDLLD 720
KVRRLGRELP VNTLDELIDQ LGGPQRVAEM TGRKGRVVSR PDGTVAFESR AEQGLSIDHV 780
NLREKQRFMS GEKLVAIISE ASSSGVSLQA DRRVQNQRRR VHMTLELPWS ADRAIQQFGR 840
THRSNQVSAP EYVFLISELA GERRFASIVA KRLESLGALT HGDRRATESR DLSKYNFENK 900
YGTRALHCVL TTILSQTENK VPVPQGYPGG VPTFFRDMKQ GLLSVGIGGR ESRNGCLDVE 960
KDCSITKFLN RILGLEVHKQ NALFQYFSDT FDHLIEMDKR EGKYDMGILD LAPGIEEIYE 1020
ESQQVFLAPG HPQDGQVVFY KISVDRGLKW EDAFAKSLAL TGPYDGFYLS YKVRGNKPSC 1080
LLAEQNRGQF FTVYKPNIGR QSQLEALDSL RRKFHRVTAE EAKEPWESGY ALSLTHCSHS 1140
AWNRHCRLAQ EGKDCLQGLR LRHHYMLCGA LLRVWGRIAA VMADVSSSSY LQIVRLKTKD 1200
RKKQVGIKIP EGCVRRVLQE LRLMDADVKR RQAPALGCPA PPAPRPLALP CGPGEVLDLT 1260
YSPPAEAFPP PPHFSFPAPL SLDAGPGVVP LGTPDAQADP AALAHQGCDI NFKEVLEDML 1320
RSLHAGPPSE GALGEGAGAG GAAGGGPERQ SVIQFSPPFP GAQAPL 1366 
Gene Ontology
 GO:0002281; P:macrophage activation involved in immune response; IMP:UniProtKB.
 GO:0045892; P:negative regulation of transcription, DNA-dependent; IMP:UniProtKB.
 GO:0050727; P:regulation of inflammatory response; IMP:UniProtKB.
 GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW. 
Interpro
 IPR027417; P-loop_NTPase.
 IPR026937; SBNO_Helicase_C_dom.
 IPR026741; SNO-like. 
Pfam
 PF13871; Helicase_C_4 
SMART
  
PROSITE
  
PRINTS