UniProt Accession

 CGHB_HUMAN; P01233; A1A5E0; B9ZVP5; Q13991; Q14000; Q3KPI3; Q3SY41; Q8WTT5; Q8WXL1; Q8WXL2; Q8WXL3; Q8WXL4 

Genbank Protein ID

 J00117; X00265; X00266; K03189; K03187; K03188; K03183; K00092; K03182; BT006890; AK291552; AC008687; CH471177; CH471177; CH471177; CH471177; BC006290; BC022796; BC030994; BC041054; BC051378; BC069526; BC103969; BC103970; BC103971; BC106059; BC106723; BC106724; BC128603; M13503; M13504; M13505; AF397576; AF397577; AF397578; AF397579; AF397580; AF397581 

Genbank Nucleotide ID

 AAA96690.1; CAA25068.1; CAA25069.1; AAA53288.1; AAA53288.1; AAA53288.1; AAA53287.1; AAA53287.1; AAA53287.1; AAP35536.1; BAF84241.1; EAW52434.1; EAW52437.1; EAW52438.1; EAW52439.1; AAH06290.1; AAH22796.1; AAH30994.1; AAH41054.1; AAH51378.1; AAH69526.1; AAI03970.1; AAI03971.1; AAI03972.1; AAI06060.1; AAI06724.1; AAI06725.1; AAI28604.1; AAA52009.1; AAA52005.1; AAA52008.1; AAL69704.1; AAL69705.1; AAL69706.1; AAL69707.1; AAL69708.1; AAL69709.1 

Protein Name

 Choriogonadotropin subunit beta 

Protein Synonyms/Alias

 CG-beta; Chorionic gonadotrophin chain beta 

Gene Name

 CGB; CGB5; CGB7; CGB8 

Gene Synonyms/Alias

 CGB3 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
22	MGGTWASKEPLRPRC	acetylation	[1]
124	TTDCGGPKDHPLTCD	acetylation	[1]

Reference

 [1] A label selection approach to assess the role of individual amino groups in human choriogonadotropin receptor binding.
 Yadav SP, Brew K, Majercik MH, Puett D.
 J Biol Chem. 1994 Feb 11;269(6):3991-8. [PMID: 8307955] 

Functional Description

 Stimulates the ovaries to synthesize the steroids that are essential for the maintenance of pregnancy. 

Sequence Annotation

 CARBOHYD 33 33 N-linked (GlcNAc...).
 CARBOHYD 50 50 N-linked (GlcNAc...).
 CARBOHYD 141 141 O-linked (GalNAc...).
 CARBOHYD 147 147 O-linked (GalNAc...).
 CARBOHYD 152 152 O-linked (GalNAc...).
 CARBOHYD 158 158 O-linked (GalNAc...).
 DISULFID 29 77
 DISULFID 43 92
 DISULFID 46 130
 DISULFID 54 108
 DISULFID 58 110
 DISULFID 113 120  

Keyword

 3D-structure; Alternative splicing; Complete proteome; Direct protein sequencing; Disulfide bond; Glycoprotein; Hormone; Pharmaceutical; Polymorphism; Reference proteome; Secreted; Signal. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 165 AA 

Protein Sequence

Gene Ontology

 GO:0005576; C:extracellular region; TAS:Reactome.
 GO:0005179; F:hormone activity; TAS:ProtInc.
 GO:0006915; P:apoptotic process; TAS:ProtInc.
 GO:0007267; P:cell-cell signaling; TAS:ProtInc.
 GO:0044267; P:cellular protein metabolic process; TAS:Reactome.
 GO:0007292; P:female gamete generation; TAS:ProtInc.
 GO:0016486; P:peptide hormone processing; TAS:Reactome.
 GO:0007165; P:signal transduction; TAS:ProtInc. 

Interpro

 IPR006208; Cys_knot.
 IPR001545; Gonadotropin_bsu.
 IPR018245; Gonadotropin_bsu_CS. 

Pfam

 PF00007; Cys_knot 

SMART

 SM00068; GHB 

PROSITE

 PS00261; GLYCO_HORMONE_BETA_1
 PS00689; GLYCO_HORMONE_BETA_2 

PRINTS