CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-018450
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Apolipoprotein F 
Protein Synonyms/Alias
 Apo-F; Leukemia virus-inactivating factor; LVIF 
Gene Name
 Apof 
Gene Synonyms/Alias
 Lvif 
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
254IQYYYDEKEVTTPQPubiquitination[1]
314NYGVLAYKR******ubiquitination[1]
Reference
 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 
Functional Description
 Minor apolipoprotein that associates with LDL. Inhibits cholesteryl ester transfer protein (CETP) activity and appears to be an important regulator of cholesterol transport. Also associates to a lesser degree with VLDL, Apo-AI and Apo-AII (By similarity). 
Sequence Annotation
  
Keyword
 Cholesterol metabolism; Cleavage on pair of basic residues; Complete proteome; HDL; LDL; Lipid metabolism; Lipid transport; Reference proteome; Secreted; Signal; Steroid metabolism; Sterol metabolism; Transport. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 315 AA 
Protein Sequence
MHSLRLILMS IQLLCYLLLC PVDATSHGEA TSVSTVLPPS KLGYQMQTSD KPLSCQMLLP 60
KSLPGFTYMP PVSKFLVGLA LRNALEAAGC QAEVWALQLQ LYRLGGVEAT QALIHHLQEL 120
QKSGHTDREV SVDALSSALQ LLAWEQPGPK RAKRSISNTD CDNDQEQSVH NVVDLLPAVG 180
TYYNLGTALY YAIKNCSDKA KERGRDGAID LGYDLLMAMV GASGGPAGAV ITAALKPAMK 240
AGVQRLIQYY YDEKEVTTPQ PEVTTHQPET GKDATTDIGV VEEIAMSNFV SEVESTTSNW 300
EWPLLKNYGV LAYKR 315 
Gene Ontology
 GO:0034364; C:high-density lipoprotein particle; IEA:UniProtKB-KW.
 GO:0034362; C:low-density lipoprotein particle; IEA:UniProtKB-KW.
 GO:0033344; P:cholesterol efflux; IGI:MGI.
 GO:0008203; P:cholesterol metabolic process; IMP:MGI.
 GO:0006641; P:triglyceride metabolic process; IMP:MGI. 
Interpro
 IPR026114; APOF. 
Pfam
  
SMART
  
PROSITE
  
PRINTS