UniProt Accession

 MCTS1_MOUSE; Q9DB27; Q3UUI6 

Genbank Protein ID

 AK005292; AK087975; AK138385; AL513356; AL845279; AL845279; AL513356; BC010486 

Genbank Nucleotide ID

 BAB23936.1; BAC40069.1; BAE23639.1; CAM17146.1; CAM17146.1; CAM20158.1; CAM20158.1; AAH10486.1 

Protein Name

 Malignant T-cell-amplified sequence 1 

Protein Synonyms/Alias

 MCT-1; Multiple copies T-cell malignancies 1 

Gene Name

 Mcts1 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
18	VSNCIQLKTSVIKGI	ubiquitination	[1]
157	MSAEDIEKVNKGIGI	acetylation	[2]
160	EDIEKVNKGIGIENI	ubiquitination	[1]

Reference

 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023]
 [2] Quantitative acetylome analysis reveals the roles of SIRT1 in regulating diverse substrates and cellular pathways.
 Chen Y, Zhao W, Yang JS, Cheng Z, Luo H, Lu Z, Tan M, Gu W, Zhao Y.
 Mol Cell Proteomics. 2012 Oct;11(10):1048-62. [PMID: 22826441] 

Functional Description

 Anti-oncogene that play a role in cell cycle regulation; decreases cell doubling time and anchorage-dependent growth; shortens the duration of G1 transit time and G1/S transition. When constituvely expressed, increases CDK4 and CDK6 kinases activity and CCND1/cyclin D1 protein level, as well as G1 cyclin/CDK complex formation. Plays a role as translation enhancer; Recruits the density-regulated protein/DENR and binds to the cap complex of the 5'-terminus of mRNAs, subsequently altering the mRNA translation profile; Up-regulates protein levels of BCL2L2, TFDP1, MRE11A, CCND1 and E2F1, while mRNA levels remains constant. Hyperactivates DNA damage signaling pathway; increased gamma- irradiation-induced phosphorylation of histone H2AX, and induces damage foci formation. Increases the overall number of chromosomal abnormalities such as larger chromosomes formation and multiples chromosomal fusions when overexpressed in gamma-irradiated cells. May play a role in promoting lymphoid tumor development: lymphoid cell lines overexpressing MCTS1 exhibit increased growth rates and display increased protection against apoptosis. May contribute to the pathogenesis and progression of breast cancer via promotion of angiogenesis through the decline of inhibitory THBS1/thrombospondin-1, and inhibition of apoptosis. Involved in the process of proteasome degradation to down-regulate Tumor suppressor p53/TP53 in breast cancer cell; Positively regulates phosphorylation of MAPK1 and MAPK3 (By similarity). 

Sequence Annotation

 DOMAIN 92 171 PUA.
 MOD_RES 81 81 Phosphothreonine (By similarity).
 MOD_RES 118 118 Phosphoserine (By similarity).  

Keyword

 Alternative splicing; Cell cycle; Complete proteome; Cytoplasm; DNA damage; Growth regulation; Phosphoprotein; Reference proteome; Transcription; Transcription regulation; Tumor suppressor. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 181 AA 

Protein Sequence

Gene Ontology

 GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
 GO:0003723; F:RNA binding; IEA:InterPro.
 GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
 GO:0040008; P:regulation of growth; IEA:UniProtKB-KW.
 GO:0006355; P:regulation of transcription, DNA-dependent; IEA:UniProtKB-KW.
 GO:0006974; P:response to DNA damage stimulus; IEA:UniProtKB-KW.
 GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW. 

Interpro

 IPR002478; PUA.
 IPR015947; PUA-like_domain.
 IPR016437; Transl_RNA-bd_prd.
 IPR004521; Uncharacterised_CHP00451. 

Pfam

 PF01472; PUA 

SMART

 SM00359; PUA 

PROSITE

 PS50890; PUA 

PRINTS