Tag | Content |
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CPLM ID | CPLM-004605 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Hexokinase-1 |
Protein Synonyms/Alias | Hexokinase type I; HK I; Hexokinase, tumor isozyme |
Gene Name | Hk1 |
Gene Synonyms/Alias | |
Created Date | July 27, 2013 |
Organism | Mus musculus (Mouse) |
NCBI Taxa ID | 10090 |
Lysine Modification | Position | Peptide | Type | References |
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21 | LKDDQVKKIDKYLYA | ubiquitination | [1] | 24 | DQVKKIDKYLYAMRL | ubiquitination | [1] | 62 | YNPTASVKMLPTFVR | ubiquitination | [1] | 77 | SIPDGSEKGDFIALD | ubiquitination | [1] | 147 | KRKIKDKKLPVGFTF | ubiquitination | [1] | 187 | VEGADVVKLLNKAIK | ubiquitination | [1] | 315 | LILVKMAKESLLFEG | ubiquitination | [1] | 333 | PELLTRGKFTTSDVA | ubiquitination | [1] | 346 | VAAIETDKEGVQNAK | ubiquitination | [1] | 418 | GVDGSLYKMHPQYSR | ubiquitination | [1] | 451 | LSESGSGKGAAMVTA | ubiquitination | [1] | 488 | KQALMEVKKKLRSEM | ubiquitination | [1] | 510 | TNSRATVKMLPSYVR | ubiquitination | [1] | 624 | ITWTKGFKATDCVGH | ubiquitination | [1] | 763 | NILIDFTKKGFLFRG | ubiquitination | [1] | 777 | GQISEPLKTRGIFET | ubiquitination | [1] | 828 | TVCGVVSKRAAQLCG | ubiquitination | [1] | 844 | GMAAVVEKIRENRGL | ubiquitination | [1] | 885 | TVKELSPKCTVSFLL | ubiquitination | [1] |
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Reference | [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues. Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C. Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [ PMID: 22790023] |
Functional Description | |
Sequence Annotation | NP_BIND 140 145 ATP 1 (Potential). NP_BIND 481 482 ATP 1 (By similarity). NP_BIND 588 593 ATP 2 (By similarity). NP_BIND 803 804 ATP 2 (By similarity). NP_BIND 840 844 ATP 2 (By similarity). NP_BIND 919 923 ATP 2 (By similarity). REGION 1 52 Hydrophobic. REGION 53 531 Regulatory. REGION 140 144 Glucose-6-phosphate 1 binding (By REGION 228 229 Substrate 1 binding (By similarity). REGION 264 265 Substrate 1 binding (By similarity). REGION 347 350 Substrate 1 binding (By similarity). REGION 469 471 Glucose-6-phosphate 1 binding (By REGION 532 974 Catalytic. REGION 588 592 Glucose-6-phosphate 2 binding (By REGION 659 660 Substrate 2 binding (By similarity). REGION 676 677 Substrate 2 binding (By similarity). REGION 712 713 Substrate 2 binding (By similarity). REGION 917 919 Glucose-6-phosphate 2 binding (By BINDING 86 86 ATP 1 (By similarity). BINDING 211 211 Substrate 1 (By similarity). BINDING 265 265 Glucose-6-phosphate 1 (By similarity). BINDING 288 288 Glucose-6-phosphate 1 (By similarity). BINDING 291 291 Substrate 1 (By similarity). BINDING 316 316 Substrate 1 (By similarity). BINDING 505 505 Glucose-6-phosphate 1 (By similarity). BINDING 659 659 Glucose-6-phosphate 2 (By similarity). BINDING 713 713 Glucose-6-phosphate 2 (By similarity). BINDING 736 736 ATP 2 (By similarity). BINDING 736 736 Glucose-6-phosphate 2 (By similarity). BINDING 739 739 Substrate 2 (By similarity). BINDING 764 764 Substrate 2 (By similarity). BINDING 798 798 Substrate 2 (By similarity). BINDING 953 953 Glucose-6-phosphate 2 (By similarity). MOD_RES 83 83 Phosphotyrosine. |
Keyword | Allosteric enzyme; Alternative initiation; Alternative splicing; ATP-binding; Complete proteome; Direct protein sequencing; Glycolysis; Kinase; Membrane; Mitochondrion; Mitochondrion outer membrane; Nucleotide-binding; Phosphoprotein; Reference proteome; Repeat; Transferase. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 974 AA |
Protein Sequence | MIAAQLLAYY FTELKDDQVK KIDKYLYAMR LSDEILIDIL TRFKKEMKNG LSRDYNPTAS 60 VKMLPTFVRS IPDGSEKGDF IALDLGGSSF RILRVQVNHE KSQNVSMESE VYDTPENIVH 120 GSGSQLFDHV AECLGDFMEK RKIKDKKLPV GFTFSFPCRQ SKIDEAVLIT WTKRFKASGV 180 EGADVVKLLN KAIKKRGDYD ANIVAVVNDT VGTMMTCGYD DQQCEVGLII GTGTNACYME 240 ELRHIDLVEG DEGRMCINTE WGAFGDDGSL EDIRTEFDRE LDRGSLNPGK QLFEKMVSGM 300 YMGELVRLIL VKMAKESLLF EGRITPELLT RGKFTTSDVA AIETDKEGVQ NAKEILTRLG 360 VEPSHDDCVS VQHVCTIVSF RSANLVAATL GAILNRLRDN KGTPRLRTTV GVDGSLYKMH 420 PQYSRRFHKT LRRLVPDSDV RFLLSESGSG KGAAMVTAVA YRLAEQHRQI EETLSHFRLS 480 KQALMEVKKK LRSEMEMGLR KETNSRATVK MLPSYVRSIP DGTEHGDFLA LDLGGTNFRV 540 LLVKIRSGKK RTVEMHNKIY SIPLEIMQGT GDELFDHIVS CISDFLDYMG IKGPRMPLGF 600 TFSFPCKQTS LDCGILITWT KGFKATDCVG HDVATLLRDA VKRREEFDLD VVAVVNDTVG 660 TMMTCAYEEP SCEIGLIVGT GSNACYMEEM KNVEMVEGNQ GQMCINMEWG AFGDNGCLDD 720 IRTDFDKVVD EYSLNSGKQR FEKMISGMYL GEIVRNILID FTKKGFLFRG QISEPLKTRG 780 IFETKFLSQI ESDRLALLQV RAILQQLGLN STCDDSILVK TVCGVVSKRA AQLCGAGMAA 840 VVEKIRENRG LDHLNVTVGV DGTLYKLHPH FSRIMHQTVK ELSPKCTVSF LLSEDGSGKG 900 AALITAVGVR LRGDPTNA 918 |
Gene Ontology | |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |