UniProt Accession

 PDXA_ECOLI; P19624 

Genbank Protein ID

 M68521; U00096; AP009048 

Genbank Nucleotide ID

 AAA24305.1; AAC73163.1; BAB96619.1 

Protein Name

 4-hydroxythreonine-4-phosphate dehydrogenase 

Protein Synonyms/Alias

 4-(phosphohydroxy)-L-threonine dehydrogenase 

Gene Name

 pdxA 

Gene Synonyms/Alias

 b0052; JW0051 

Created Date

 July 27, 2013 

Organism

 Escherichia coli (strain K12) 

NCBI Taxa ID

 83333 

Lysine Modification

Position	Peptide	Type	References
253	ADTLFQPKYLDNADA	acetylation	[1]

Reference

 [1] Acetyl-Phosphate Is a Critical Determinant of Lysine Acetylation in E. coli.
 Weinert BT, Iesmantavicius V, Wagner SA, Schölz C, Gummesson B, Beli P, Nyström T, Choudhary C.
 Mol Cell. 2013 Jul 25;51(2):265-72. [PMID: 23830618] 

Functional Description

 Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP). 

Sequence Annotation

 METAL 166 166 Divalent metal cation; shared with
 METAL 211 211 Divalent metal cation; shared with
 METAL 266 266 Divalent metal cation; shared with
 BINDING 136 136 Substrate.
 BINDING 137 137 Substrate.
 BINDING 274 274 Substrate.
 BINDING 283 283 Substrate.
 BINDING 292 292 Substrate.  

Keyword

 3D-structure; Cobalt; Complete proteome; Cytoplasm; Magnesium; Metal-binding; NAD; NADP; Oxidoreductase; Pyridoxine biosynthesis; Reference proteome; Zinc. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 329 AA 

Protein Sequence

Gene Ontology

 GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
 GO:0050570; F:4-hydroxythreonine-4-phosphate dehydrogenase activity; IDA:EcoCyc.
 GO:0050897; F:cobalt ion binding; IEA:HAMAP.
 GO:0000287; F:magnesium ion binding; IDA:EcoCyc.
 GO:0051287; F:NAD binding; IDA:EcoCyc.
 GO:0008270; F:zinc ion binding; IDA:EcoCyc.
 GO:0042823; P:pyridoxal phosphate biosynthetic process; IMP:EcoCyc.
 GO:0008615; P:pyridoxine biosynthetic process; IMP:EcoCyc. 

Interpro

 IPR024084; IsoPropMal-DH-like_dom.
 IPR005255; PdxA. 

Pfam

 PF04166; PdxA 

SMART

  

PROSITE

  

PRINTS