CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-018051
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Pantothenate kinase 1 
Protein Synonyms/Alias
 hPanK; hPanK1; Pantothenic acid kinase 1 
Gene Name
 PANK1 
Gene Synonyms/Alias
 PANK 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
304NLTMCGRKGNLHFIRubiquitination[1]
511EKRDSISKEDLARATubiquitination[1, 2]
Reference
 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302] 
Functional Description
 Plays a role in the physiological regulation of the intracellular CoA concentration (By similarity). 
Sequence Annotation
 BINDING 417 417 Acetyl-CoA.
 BINDING 420 420 Acetyl-CoA.
 BINDING 432 432 Acetyl-CoA.
 MOD_RES 215 215 Phosphoserine.  
Keyword
 3D-structure; Alternative splicing; ATP-binding; Coenzyme A biosynthesis; Complete proteome; Cytoplasm; Kinase; Nucleotide-binding; Phosphoprotein; Reference proteome; Transferase. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 598 AA 
Protein Sequence
MLKLVGGGGG QDWACSVAGT SLGGEEAAFE VARPGDQGKA GGGSPGWGCA GIPDSAPGAG 60
VLQAGAVGPA RGGQGAEEVG ESAGGGEERR VRHPQAPALR LLNRKPQGGS GEIKTPENDL 120
QRGRLSRGPR TAPPAPGMGD RSGQQERSVP HSPGAPVGTS AAAVNGLLHN GFHPPPVQPP 180
HVCSRGPVGG SDAAPQRLPL LPELQPQPLL PQHDSPAKKC RLRRRMDSGR KNRPPFPWFG 240
MDIGGTLVKL VYFEPKDITA EEEQEEVENL KSIRKYLTSN TAYGKTGIRD VHLELKNLTM 300
CGRKGNLHFI RFPSCAMHRF IQMGSEKNFS SLHTTLCATG GGAFKFEEDF RMIADLQLHK 360
LDELDCLIQG LLYVDSVGFN GKPECYYFEN PTNPELCQKK PYCLDNPYPM LLVNMGSGVS 420
ILAVYSKDNY KRVTGTSLGG GTFLGLCCLL TGCETFEEAL EMAAKGDSTN VDKLVKDIYG 480
GDYERFGLQG SAVASSFGNM MSKEKRDSIS KEDLARATLV TITNNIGSIA RMCALNENID 540
RVVFVGNFLR INMVSMKLLA YAMDFWSKGQ LKALFLEHEG YFGAVGALLE LFKMTDDK 598 
Gene Ontology
 GO:0071944; C:cell periphery; IEA:Compara.
 GO:0005829; C:cytosol; TAS:Reactome.
 GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
 GO:0004594; F:pantothenate kinase activity; IEA:EC.
 GO:0015937; P:coenzyme A biosynthetic process; IEA:UniProtKB-UniPathway.
 GO:0009108; P:coenzyme biosynthetic process; TAS:Reactome.
 GO:0015939; P:pantothenate metabolic process; TAS:Reactome. 
Interpro
 IPR004567; Type_II_PanK. 
Pfam
 PF03630; Fumble 
SMART
  
PROSITE
  
PRINTS