UniProt Accession

 E0CYT5_MOUSE; E0CYT5 

Genbank Protein ID

 AC124336 

Genbank Nucleotide ID

  

Protein Name

 Cullin-2 

Protein Synonyms/Alias

  

Gene Name

 Cul2 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
16	DFDETWNKLLTTIKA	ubiquitination	[1]
175	NCSQYMEKVLGRLKD	ubiquitination	[1]
228	SIIQQERKNDMANMY	ubiquitination	[1]
319	VVNYREPKSVCKAPE	ubiquitination	[1]
330	KAPELLAKYCDNLLK	acetylation	[2, 3, 4]
330	KAPELLAKYCDNLLK	ubiquitination	[1]
365	VFKYIDDKDVFQKFY	ubiquitination	[1]
370	DDKDVFQKFYARMLA	ubiquitination	[1]
545	DSTQMNEKELTKTIK	ubiquitination	[1]

Reference

 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023]
 [2] Quantitative acetylome analysis reveals the roles of SIRT1 in regulating diverse substrates and cellular pathways.
 Chen Y, Zhao W, Yang JS, Cheng Z, Luo H, Lu Z, Tan M, Gu W, Zhao Y.
 Mol Cell Proteomics. 2012 Oct;11(10):1048-62. [PMID: 22826441]
 [3] Proteomic investigations of lysine acetylation identify diverse substrates of mitochondrial deacetylase sirt3.
 Sol EM, Wagner SA, Weinert BT, Kumar A, Kim HS, Deng CX, Choudhary C.
 PLoS One. 2012;7(12):e50545. [PMID: 23236377]
 [4] SIRT5-Mediated Lysine Desuccinylation Impacts Diverse Metabolic Pathways.
 Park J, Chen Y, Tishkoff DX, Peng C, Tan M, Dai L, Xie Z, Zhang Y, Zwaans BM, Skinner ME, Lombard DB, Zhao Y.
 Mol Cell. 2013 Jun 27;50(6):919-30. [PMID: 23806337] 

Functional Description

  

Sequence Annotation

  

Keyword

 Complete proteome; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 582 AA 

Protein Sequence

Gene Ontology

 GO:0031461; C:cullin-RING ubiquitin ligase complex; IEA:InterPro.
 GO:0030163; P:protein catabolic process; IMP:MGI.
 GO:0006511; P:ubiquitin-dependent protein catabolic process; IEA:InterPro. 

Interpro

 IPR016158; Cullin_homology.
 IPR001373; Cullin_N.
 IPR016159; Cullin_repeat-like_dom.
 IPR011991; WHTH_DNA-bd_dom. 

Pfam

 PF00888; Cullin 

SMART

 SM00182; CULLIN 

PROSITE

 PS50069; CULLIN_2 

PRINTS