CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-015750
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 BTB/POZ domain-containing protein KCTD9 
Protein Synonyms/Alias
  
Gene Name
 KCTD9 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
123LAHMFKDKGVWGNKQubiquitination[1]
129DKGVWGNKQDHRGAFubiquitination[1]
215FLLATPTKSELRCQGubiquitination[1, 2]
241DLRYINFKMANLSRCubiquitination[1]
279CANLQGVKMLCSNAEubiquitination[1]
302FEDPSGLKANLEGANubiquitination[1]
311NLEGANLKGVDMEGSubiquitination[1, 3, 4]
371NLRGSNVKGAIFEEMubiquitination[1, 3, 4, 5, 6, 7]
Reference
 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302]
 [3] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [4] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661]
 [5] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [6] Global identification of modular cullin-RING ligase substrates.
 Emanuele MJ, Elia AE, Xu Q, Thoma CR, Izhar L, Leng Y, Guo A, Chen YN, Rush J, Hsu PW, Yen HC, Elledge SJ.
 Cell. 2011 Oct 14;147(2):459-74. [PMID: 21963094]
 [7] hCKSAAP_UbSite: improved prediction of human ubiquitination sites by exploiting amino acid pattern and properties.
 Chen Z, Zhou Y, Song J, Zhang Z.
 Biochim Biophys Acta. 2013 Aug;1834(8):1461-7. [PMID: 23603789
Functional Description
  
Sequence Annotation
 DOMAIN 3 82 KHA.
 DOMAIN 89 161 BTB.
 DOMAIN 273 297 Pentapeptide repeat 1.
 DOMAIN 303 342 Pentapeptide repeat 2.
 DOMAIN 343 377 Pentapeptide repeat 3.  
Keyword
 Complete proteome; Reference proteome; Repeat. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 389 AA 
Protein Sequence
MRRVTLFLNG SPKNGKVVAV YGTLSDLLSV ASSKLGIKAT SVYNGKGGLI DDIALIRDDD 60
VLFVCEGEPF IDPQTDSKPP EGLLGFHTDW LTLNVGGRYF TTTRSTLVNK EPDSMLAHMF 120
KDKGVWGNKQ DHRGAFLIDR SPEYFEPILN YLRHGQLIVN DGINLLGVLE EARFFGIDSL 180
IEHLEVAIKN SQPPEDHSPI SRKEFVRFLL ATPTKSELRC QGLNFSGADL SRLDLRYINF 240
KMANLSRCNL AHANLCCANL ERADLSGSVL DCANLQGVKM LCSNAEGASL KLCNFEDPSG 300
LKANLEGANL KGVDMEGSQM TGINLRVATL KNAKLKNCNL RGATLAGTDL ENCDLSGCDL 360
QEANLRGSNV KGAIFEEMLT PLHMSQSVR 389 
Gene Ontology
 GO:0051260; P:protein homooligomerization; IEA:InterPro. 
Interpro
 IPR001646; 5peptide_repeat.
 IPR000210; BTB/POZ-like.
 IPR011333; BTB/POZ_fold.
 IPR021789; K_channel_plant.
 IPR003131; T1-type_BTB. 
Pfam
 PF11834; DUF3354
 PF02214; K_tetra
 PF00805; Pentapeptide 
SMART
 SM00225; BTB 
PROSITE
 PS50097; BTB
 PS51490; KHA 
PRINTS