CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-016700
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Copine-1 
Protein Synonyms/Alias
 Copine I 
Gene Name
 Cpne1 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
156DKKDFLGKSDPFLEFubiquitination[1]
Reference
 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023
Functional Description
 May function in membrane trafficking. Exhibits calcium- dependent phospholipid binding properties. 
Sequence Annotation
 DOMAIN 1 97 C2 1.
 DOMAIN 143 227 C2 2.
 DOMAIN 284 504 VWFA.
 MOD_RES 170 170 N6-acetyllysine (By similarity).
 MOD_RES 525 525 Phosphothreonine.  
Keyword
 Acetylation; Complete proteome; Phosphoprotein; Reference proteome; Repeat. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 536 AA 
Protein Sequence
MAHCVTLVQL SVSCEHLIDK DIGSKSDPLC VLLQDVGGAW AELCRTERVR NCSSPEFSKT 60
LQIEYHFETV QKLRFGIYDI DNKTPELGDD DFLGGAECSL GQIVSSQTLT LPLMLKPGKP 120
AGRGTITVSA QELKDSRVVT MEVEARNLDK KDFLGKSDPF LEFFRQGDGK WQLAYRTEVV 180
KNNLNPTWKR FSVSLQHFCG GDLSTPIQVR CSDYDSDGSH DLIGTFHTTL AQLQAVPAEF 240
ECVHPEKQQR KKNYRNSGTV RVKTCRVETE YSFLDYVMGG CQINFTVGVD FTGSNGDPSS 300
PDSLHYLSPT GVNEYLTALW SVGSVVQDYD SDKLFPAFGF GAQVPPDWQV SHEFALNFNP 360
SNPYCAGIQG IVDAYRQALP QVRLYGPTNF APIINHVARF AAQAAQQRSA SQYFVLLLLT 420
DGAVTDVEAT CKAVVDASKL PMSVIIVGVG GADFEVMEQL DADGGPLRTR SGEAAARDIV 480
QFVPYRRFQN APRETLAQTV LAEVPTQMVS YFRAQGWAPL KAPPTPGKGP AQAPQA 536 
Gene Ontology
 GO:0005634; C:nucleus; IEA:Compara.
 GO:0001786; F:phosphatidylserine binding; IEA:Compara. 
Interpro
 IPR000008; C2_Ca-dep.
 IPR008973; C2_Ca/lipid-bd_dom_CaLB.
 IPR018029; C2_membr_targeting.
 IPR010734; Copine.
 IPR002035; VWF_A. 
Pfam
 PF00168; C2
 PF07002; Copine 
SMART
 SM00239; C2
 SM00327; VWA 
PROSITE
 PS50004; C2
 PS50234; VWFA 
PRINTS