UniProt Accession

 CRYM_MOUSE; O54983 

Genbank Protein ID

 AF039391; BC045159 

Genbank Nucleotide ID

 AAB94770.1; AAH45159.1 

Protein Name

 Thiomorpholine-carboxylate dehydrogenase 

Protein Synonyms/Alias

 Mu-crystallin homolog; NADP-regulated thyroid-hormone-binding protein; ketimine reductase 

Gene Name

 Crym 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
290	CEKTTVFKSLGMAVE	ubiquitination	[1]

Reference

 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 

Functional Description

 Specifically catalyzes the reduction of imine bonds in brain substrates that may include cystathionine ketimine (CysK) and lanthionine ketimine (LK). Binds thyroid hormone which is a strong reversible inhibitor. Presumably involved in the regulation of the free intracellular concentration of triiodothyronine and access to its nuclear receptors (By similarity). 

Sequence Annotation

 NP_BIND 142 147 NADP (By similarity).
 BINDING 167 167 NADP (By similarity).
 BINDING 168 168 NADP (By similarity).  

Keyword

 Complete proteome; Cytoplasm; Direct protein sequencing; NAD; NADP; Oxidoreductase; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 313 AA 

Protein Sequence

Gene Ontology

 GO:0005739; C:mitochondrion; IDA:MGI.
 GO:0005634; C:nucleus; IDA:MGI.
 GO:0005886; C:plasma membrane; IEA:Compara.
 GO:0042562; F:hormone binding; IMP:MGI.
 GO:0050661; F:NADP binding; IEA:Compara.
 GO:0047127; F:thiomorpholine-carboxylate dehydrogenase activity; IEA:EC.
 GO:0070324; F:thyroid hormone binding; IEA:Compara.
 GO:0003714; F:transcription corepressor activity; IEA:Compara.
 GO:0000122; P:negative regulation of transcription from RNA polymerase II promoter; IEA:Compara.
 GO:0007605; P:sensory perception of sound; IEA:Compara.
 GO:0042403; P:thyroid hormone metabolic process; IMP:MGI.
 GO:0070327; P:thyroid hormone transport; IEA:Compara. 

Interpro

 IPR016040; NAD(P)-bd_dom.
 IPR003462; ODC_Mu_crystall.
 IPR023401; ODC_N. 

Pfam

 PF02423; OCD_Mu_crystall 

SMART

  

PROSITE

  

PRINTS