UniProt Accession

 F6XX57_MOUSE; F6XX57 

Genbank Protein ID

 AC154452; AC154471 

Genbank Nucleotide ID

  

Protein Name

 DNA topoisomerase 2-beta 

Protein Synonyms/Alias

  

Gene Name

 Top2b 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
185	KTPTSTGKTNAKKVK	acetylation	[1]

Reference

 [1] SIRT5-Mediated Lysine Desuccinylation Impacts Diverse Metabolic Pathways.
 Park J, Chen Y, Tishkoff DX, Peng C, Tan M, Dai L, Xie Z, Zhang Y, Zwaans BM, Skinner ME, Lombard DB, Zhao Y.
 Mol Cell. 2013 Jun 27;50(6):919-30. [PMID: 23806337] 

Functional Description

  

Sequence Annotation

  

Keyword

 Complete proteome; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 348 AA 

Protein Sequence

Gene Ontology

 GO:0000795; C:synaptonemal complex; IBA:RefGenome.
 GO:0071778; C:WINAC complex; IBA:RefGenome.
 GO:0005524; F:ATP binding; IEA:InterPro.
 GO:0003682; F:chromatin binding; IBA:RefGenome.
 GO:0003918; F:DNA topoisomerase type II (ATP-hydrolyzing) activity; IBA:RefGenome.
 GO:0042826; F:histone deacetylase binding; IBA:RefGenome.
 GO:0005080; F:protein kinase C binding; IBA:RefGenome.
 GO:0007409; P:axonogenesis; IMP:MGI.
 GO:0006265; P:DNA topological change; IBA:RefGenome.
 GO:0006261; P:DNA-dependent DNA replication; IBA:RefGenome.
 GO:0030900; P:forebrain development; IMP:MGI.
 GO:0044774; P:mitotic DNA integrity checkpoint; IBA:RefGenome.
 GO:0006312; P:mitotic recombination; IBA:RefGenome.
 GO:0001764; P:neuron migration; IMP:MGI.
 GO:0000712; P:resolution of meiotic recombination intermediates; IBA:RefGenome.
 GO:0000819; P:sister chromatid segregation; IBA:RefGenome. 

Interpro

 IPR002205; Topo_IIA_A/C.
 IPR013757; Topo_IIA_A_a.
 IPR013760; Topo_IIA_like_dom. 

Pfam

 PF00521; DNA_topoisoIV 

SMART

  

PROSITE

  

PRINTS