CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-021816
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Secretory carrier-associated membrane protein 5 
Protein Synonyms/Alias
 Secretory carrier membrane protein 5 
Gene Name
 Scamp5 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
4****MAEKVNNFPPLubiquitination[1]
185GSGGSFSKAQEEWTTubiquitination[1]
Reference
 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 
Functional Description
 Required for the calcium-dependent exocytosis of signal sequence-containing cytokines such as CCL5. Probably acts in cooperation with the SNARE machinery (By similarity). 
Sequence Annotation
  
Keyword
 Cell junction; Cell membrane; Complete proteome; Cytoplasmic vesicle; Endosome; Exocytosis; Golgi apparatus; Membrane; Protein transport; Reference proteome; Synapse; Transmembrane; Transmembrane helix; Transport. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 235 AA 
Protein Sequence
MAEKVNNFPP LPKFIPLKPC FYQDFEADIP PQHLSLTKRL YYLWMLNSVT LAVNLVGCLA 60
WLIGGGGATN FGLAFLWLIL FTPCSYVCWF RPIYKAFKTD SSFSFMAFFF TFMAQLVISI 120
IQAVGIPGWG VCGWIATISF FGTNIGSAVV MLIPTVMFTV VAVFSFIALS MVHKFYRGSG 180
GSFSKAQEEW TTGAWKNPHV QQAAQNAAMG AAQGAMNQPQ TQYSATPNYT YSNEM 235 
Gene Ontology
 GO:0030054; C:cell junction; IEA:UniProtKB-KW.
 GO:0000139; C:Golgi membrane; ISS:UniProtKB.
 GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
 GO:0005886; C:plasma membrane; ISS:UniProtKB.
 GO:0055038; C:recycling endosome membrane; IEA:UniProtKB-SubCell.
 GO:0031201; C:SNARE complex; IEA:Compara.
 GO:0008021; C:synaptic vesicle; ISS:MGI.
 GO:0030672; C:synaptic vesicle membrane; IEA:UniProtKB-SubCell.
 GO:0032588; C:trans-Golgi network membrane; IEA:Compara.
 GO:0006887; P:exocytosis; IEA:UniProtKB-KW.
 GO:0045806; P:negative regulation of endocytosis; IEA:Compara.
 GO:0045956; P:positive regulation of calcium ion-dependent exocytosis; ISS:UniProtKB.
 GO:0050715; P:positive regulation of cytokine secretion; ISS:UniProtKB.
 GO:0015031; P:protein transport; IEA:UniProtKB-KW.
 GO:0034976; P:response to endoplasmic reticulum stress; IEA:Compara. 
Interpro
 IPR007273; SCAMP. 
Pfam
 PF04144; SCAMP 
SMART
  
PROSITE
  
PRINTS