CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-012325
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Sodium channel protein type 5 subunit alpha 
Protein Synonyms/Alias
 HH1; Sodium channel protein cardiac muscle subunit alpha; Sodium channel protein type V subunit alpha; Voltage-gated sodium channel subunit alpha Nav1.5 
Gene Name
 SCN5A 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
1885FMAANPSKISYEPITubiquitination[1]
Reference
 [1] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661] 
Functional Description
 This protein mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient. It is a tetrodotoxin-resistant Na(+) channel isoform. This channel is responsible for the initial upstroke of the action potential. Channel inactivation is regulated by intracellular calcium levels. 
Sequence Annotation
 DOMAIN 1901 1930 IQ.
 REGION 1974 1977 Interaction with NEDD4, NEDD4L and WWP2.
 MOD_RES 513 513 Dimethylated arginine; alternate.
 MOD_RES 513 513 Omega-N-methylarginine; alternate.
 MOD_RES 526 526 Dimethylated arginine; alternate.
 MOD_RES 526 526 Omega-N-methylarginine; alternate.
 MOD_RES 680 680 Dimethylated arginine; alternate.
 MOD_RES 680 680 Omega-N-methylarginine; alternate.
 CARBOHYD 214 214 N-linked (GlcNAc...) (Potential).
 CARBOHYD 283 283 N-linked (GlcNAc...) (Potential).
 CARBOHYD 288 288 N-linked (GlcNAc...) (Potential).
 CARBOHYD 291 291 N-linked (GlcNAc...) (Potential).
 CARBOHYD 318 318 N-linked (GlcNAc...) (Potential).
 CARBOHYD 328 328 N-linked (GlcNAc...) (Potential).
 CARBOHYD 548 548 N-linked (GlcNAc...) (Potential).
 CARBOHYD 592 592 N-linked (GlcNAc...) (Potential).
 CARBOHYD 740 740 N-linked (GlcNAc...) (Potential).
 CARBOHYD 803 803 N-linked (GlcNAc...) (Potential).
 CARBOHYD 841 841 N-linked (GlcNAc...) (Potential).
 CARBOHYD 864 864 N-linked (GlcNAc...) (Potential).
 CARBOHYD 946 946 N-linked (GlcNAc...) (Potential).
 CARBOHYD 1365 1365 N-linked (GlcNAc...) (Potential).
 CARBOHYD 1374 1374 N-linked (GlcNAc...) (Potential).
 CARBOHYD 1380 1380 N-linked (GlcNAc...) (Potential).
 CARBOHYD 1388 1388 N-linked (GlcNAc...) (Potential).
 CARBOHYD 1736 1736 N-linked (GlcNAc...) (Potential).
 CARBOHYD 1774 1774 N-linked (GlcNAc...) (Potential).
 CARBOHYD 1955 1955 N-linked (GlcNAc...) (Potential).  
Keyword
 3D-structure; Alternative splicing; Atrial fibrillation; Brugada syndrome; Calmodulin-binding; Cardiomyopathy; Complete proteome; Disease mutation; Glycoprotein; Ion channel; Ion transport; Long QT syndrome; Membrane; Methylation; Phosphoprotein; Polymorphism; Reference proteome; Repeat; Sodium; Sodium channel; Sodium transport; Transmembrane; Transmembrane helix; Transport; Ubl conjugation; Voltage-gated channel. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 2016 AA 
Protein Sequence
MANFLLPRGT SSFRRFTRES LAAIEKRMAE KQARGSTTLQ ESREGLPEEE APRPQLDLQA 60
SKKLPDLYGN PPQELIGEPL EDLDPFYSTQ KTFIVLNKGK TIFRFSATNA LYVLSPFHPI 120
RRAAVKILVH SLFNMLIMCT ILTNCVFMAQ HDPPPWTKYV EYTFTAIYTF ESLVKILARG 180
FCLHAFTFLR DPWNWLDFSV IIMAYTTEFV DLGNVSALRT FRVLRALKTI SVISGLKTIV 240
GALIQSVKKL ADVMVLTVFC LSVFALIGLQ LFMGNLRHKC VRNFTALNGT NGSVEADGLV 300
WESLDLYLSD PENYLLKNGT SDVLLCGNSS DAGTCPEGYR CLKAGENPDH GYTSFDSFAW 360
AFLALFRLMT QDCWERLYQQ TLRSAGKIYM IFFMLVIFLG SFYLVNLILA VVAMAYEEQN 420
QATIAETEEK EKRFQEAMEM LKKEHEALTI RGVDTVSRSS LEMSPLAPVN SHERRSKRRK 480
RMSSGTEECG EDRLPKSDSE DGPRAMNHLS LTRGLSRTSM KPRSSRGSIF TFRRRDLGSE 540
ADFADDENST AGESESHHTS LLVPWPLRRT SAQGQPSPGT SAPGHALHGK KNSTVDCNGV 600
VSLLGAGDPE ATSPGSHLLR PVMLEHPPDT TTPSEEPGGP QMLTSQAPCV DGFEEPGARQ 660
RALSAVSVLT SALEELEESR HKCPPCWNRL AQRYLIWECC PLWMSIKQGV KLVVMDPFTD 720
LTITMCIVLN TLFMALEHYN MTSEFEEMLQ VGNLVFTGIF TAEMTFKIIA LDPYYYFQQG 780
WNIFDSIIVI LSLMELGLSR MSNLSVLRSF RLLRVFKLAK SWPTLNTLIK IIGNSVGALG 840
NLTLVLAIIV FIFAVVGMQL FGKNYSELRD SDSGLLPRWH MMDFFHAFLI IFRILCGEWI 900
ETMWDCMEVS GQSLCLLVFL LVMVIGNLVV LNLFLALLLS SFSADNLTAP DEDREMNNLQ 960
LALARIQRGL RFVKRTTWDF CCGLLRQRPQ KPAALAAQGQ LPSCIATPYS PPPPETEKVP 1020
PTRKETRFEE GEQPGQGTPG DPEPVCVPIA VAESDTDDQE EDEENSLGTE EESSKQESQP 1080
VSGGPEAPPD SRTWSQVSAT ASSEAEASAS QADWRQQWKA EPQAPGCGET PEDSCSEGST 1140
ADMTNTAELL EQIPDLGQDV KDPEDCFTEG CVRRCPCCAV DTTQAPGKVW WRLRKTCYHI 1200
VEHSWFETFI IFMILLSSGA LAFEDIYLEE RKTIKVLLEY ADKMFTYVFV LEMLLKWVAY 1260
GFKKYFTNAW CWLDFLIVDV SLVSLVANTL GFAEMGPIKS LRTLRALRPL RALSRFEGMR 1320
VVVNALVGAI PSIMNVLLVC LIFWLIFSIM GVNLFAGKFG RCINQTEGDL PLNYTIVNNK 1380
SQCESLNLTG ELYWTKVKVN FDNVGAGYLA LLQVATFKGW MDIMYAAVDS RGYEEQPQWE 1440
YNLYMYIYFV IFIIFGSFFT LNLFIGVIID NFNQQKKKLG GQDIFMTEEQ KKYYNAMKKL 1500
GSKKPQKPIP RPLNKYQGFI FDIVTKQAFD VTIMFLICLN MVTMMVETDD QSPEKINILA 1560
KINLLFVAIF TGECIVKLAA LRHYYFTNSW NIFDFVVVIL SIVGTVLSDI IQKYFFSPTL 1620
FRVIRLARIG RILRLIRGAK GIRTLLFALM MSLPALFNIG LLLFLVMFIY SIFGMANFAY 1680
VKWEAGIDDM FNFQTFANSM LCLFQITTSA GWDGLLSPIL NTGPPYCDPT LPNSNGSRGD 1740
CGSPAVGILF FTTYIIISFL IVVNMYIAII LENFSVATEE STEPLSEDDF DMFYEIWEKF 1800
DPEATQFIEY SVLSDFADAL SEPLRIAKPN QISLINMDLP MVSGDRIHCM DILFAFTKRV 1860
LGESGEMDAL KIQMEEKFMA ANPSKISYEP ITTTLRRKHE EVSAMVIQRA FRRHLLQRSL 1920
KHASFLFRQQ AGSGLSEEDA PEREGLIAYV MSENFSRPLG PPSSSSISST SFPPSYDSVT 1980
RATSDNLQVR GSDYSHSEDL ADFPPSPDRD RESIV 2015 
Gene Ontology
 GO:0009986; C:cell surface; IDA:BHF-UCL.
 GO:0005783; C:endoplasmic reticulum; IDA:BHF-UCL.
 GO:0014704; C:intercalated disc; IDA:BHF-UCL.
 GO:0030315; C:T-tubule; IDA:BHF-UCL.
 GO:0001518; C:voltage-gated sodium channel complex; IDA:BHF-UCL.
 GO:0030506; F:ankyrin binding; IDA:BHF-UCL.
 GO:0086006; F:voltage-gated sodium channel activity involved in regulation of cardiac muscle cell action potential; IDA:BHF-UCL.
 GO:0086067; P:AV node cell to bundle of His cell communication; IMP:BHF-UCL.
 GO:0003360; P:brainstem development; ISS:BHF-UCL.
 GO:0086069; P:bundle of His cell to Purkinje myocyte communication; IMP:BHF-UCL.
 GO:0060048; P:cardiac muscle contraction; IMP:BHF-UCL.
 GO:0003231; P:cardiac ventricle development; ISS:BHF-UCL.
 GO:0071277; P:cellular response to calcium ion; IDA:UniProtKB.
 GO:0021549; P:cerebellum development; ISS:BHF-UCL.
 GO:0086046; P:membrane depolarization involved in regulation of SA node cell action potential; ISS:BHF-UCL.
 GO:0042475; P:odontogenesis of dentin-containing tooth; ISS:BHF-UCL.
 GO:0045760; P:positive regulation of action potential; ISS:BHF-UCL.
 GO:0050679; P:positive regulation of epithelial cell proliferation; ISS:BHF-UCL.
 GO:0010765; P:positive regulation of sodium ion transport; IDA:BHF-UCL.
 GO:0060371; P:regulation of atrial cardiac muscle cell membrane depolarization; IMP:BHF-UCL.
 GO:0060372; P:regulation of atrial cardiac muscle cell membrane repolarization; IMP:BHF-UCL.
 GO:0086091; P:regulation of heart rate by cardiac conduction; IMP:BHF-UCL.
 GO:0086005; P:regulation of ventricular cardiac muscle cell action potential; IMP:BHF-UCL.
 GO:0060373; P:regulation of ventricular cardiac muscle cell membrane depolarization; IMP:BHF-UCL.
 GO:0060307; P:regulation of ventricular cardiac muscle cell membrane repolarization; IMP:BHF-UCL.
 GO:0014894; P:response to denervation involved in regulation of muscle adaptation; ISS:BHF-UCL.
 GO:0021537; P:telencephalon development; ISS:BHF-UCL. 
Interpro
 IPR024583; DUF3451.
 IPR005821; Ion_trans_dom.
 IPR000048; IQ_motif_EF-hand-BS.
 IPR027359; K_channel_four-helix_dom.
 IPR008053; Na_channel_a5su.
 IPR001696; Na_channel_asu.
 IPR010526; Na_trans_assoc. 
Pfam
 PF11933; DUF3451
 PF00520; Ion_trans
 PF06512; Na_trans_assoc 
SMART
 SM00015; IQ 
PROSITE
 PS50096; IQ 
PRINTS
 PR00170; NACHANNEL.
 PR01666; NACHANNEL5.