CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-038231
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Protein Parp4 
Protein Synonyms/Alias
  
Gene Name
 Parp4 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
312DSPGQLQKTMAEFYRubiquitination[1]
1247VSSEVNEKPSLLLAAubiquitination[1]
1260AAKKRKIKTIKKCSLacetylation[2]
1316HGNRLEPKQRGGFRKubiquitination[1]
1643EPPLLGFKDLCSRDMubiquitination[1]
1672SKDFDPGKFSQGPNNubiquitination[1]
1898MVAKSLIKMDDAFISubiquitination[1]
Reference
 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023]
 [2] The fasted/fed mouse metabolic acetylome: N6-acetylation differences suggest acetylation coordinates organ-specific fuel switching.
 Yang L, Vaitheesvaran B, Hartil K, Robinson AJ, Hoopmann MR, Eng JK, Kurland IJ, Bruce JE.
 J Proteome Res. 2011 Sep 2;10(9):4134-49. [PMID: 21728379] 
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 1969 AA 
Protein Sequence
MTLGIFANCI FCLKVKYLPR QQKKKLQTDI KENGGKFSFL LNPQCTHVIV DSADVLSRCH 60
LNSIQKNDVQ IANPAFIQDS VRQRRLLDVR NYDPLSPAPA APPAERSRSE VQSEYLPSDN 120
TPEKENTEVT EVSAENVEIP PFLQDFEVVK YNILEKVGGP ETVVVELQSS QDPESCPFVI 180
TAHFLLADQK TRRESTGKQT SEGAIEYYES YVEDLKRQGF LLQEHFTAEA TQLASEKLQA 240
LLLEEVISSG ALSQEVSDLL EVIWTEALGH LENTLLKPVN SMSLNDVSKA EGILLLVKTA 300
LKNGDSPGQL QKTMAEFYRL LPHRHPASEE VNLRLLAQKE DLCQLVRDMV NVCETNLSKP 360
NPPSLAKYRA LRCKIEHVDQ NTEEFSRVRK EVLQNNRSEQ PVDILQIFRV GRVNEATEFL 420
SKLGNVRLLF HGSPVRNILG ILSRGLLLPK VAEDRGVQRT DVGNLGSGIY FSDSLSTSIK 480
YAHAGETDGS RLLVVCDVAL GKCVNLFKKD FSLTEAPPGY DSVHGVSETT SVPTDFQDDE 540
FVVYKTNQVK MKYIVKFCTP GDQIKEFHPH ENTEVEEQRA EPSSVPEAGD FQLPDIKPFT 600
NIKAGLQDAS ANPVPLDSVH IKGRVIDFVA QVIVFQTYTN QSHVPIEAKY IFPLDDKAAV 660
CGFEAFINGK HIVGEIKEKE EARQEYREAV SQGHGAYLMD QDTPDVFTVS VGNLPPRAKV 720
LIKITYITEL SIQSPVAIFF IPGTVAPWQQ DKALNENLQD TVETIRIKEI GAEQSFSLAM 780
SIEMPYMIEF ISSDTHELRQ KSTDCKAVVS TVEGSSLDSG GFSLHIGLRD AYLPRMWVEK 840
HPEKESEACM LVFQPELADV LPDLRGKNEV IICLDCSSSM EGVTFTQAKQ VALYALSLLG 900
EEQKVNIMQF GTGYKELFSY PKCITDSKMA TEFIMSAAPS MGNTDFWKVL RYLSLLYPSE 960
GFRNILLISD GHLQSESLTL QLVKRNIQHT RVFTCAVGST ANRHILRTLS QCGAGVFEYF 1020
NSKSKHSWKK QIEAQMTRIR SPSCHSVSVK WQQLSRDAPE PLQAPAWVPS LFHNDRLLVY 1080
GFIPHCTQAT LQAFIQEKEF CTMVSTTELQ KTTGTMIHKL AARALIRDYE DGILHDDETN 1140
HEMKKNIMKS LIIELSKENS LITQFTSFVA VEKRDVNEIP FANVPNISEL VAKEDVDFLP 1200
YVSWQEKQPE ASISQTEIDS SRLKHNKLSD GHGVLQPVSV SSEVNEKPSL LLAAKKRKIK 1260
TIKKCSLDIS EDFEDRTAVA QSPATAQSLN FHLPLSVRPQ LKAVEQQLHG NRLEPKQRGG 1320
FRKLLMAKKC RNVPDSLVSS APAVTAEFSY LSACSSSSAF LSPLCDIPSS LPPHPLGGTH 1380
PPPPLPLPDG THLPSPLFGS THPPPPLFGG TLIPPPSSLF GGTHLPPPPP LPGGTHIPPP 1440
PPIPGGTLIP PSSSLFGGTH LPPPPLLSAG THIPPPPLLS AGTHLPPPPL LPAGTHIPPP 1500
PPITGSTHPP PPSSLFGGTH LPPPPPLPGG THIPPPPPIP GGTLIPSPSS LFGGTHLPPP 1560
PLLPAGTHIP PPPPITGSTH PPPPSSLFGG THLPPPPPAG TQFSLSPIGF IPPKLGPPKL 1620
SHSHKLVGDT NIHDSEPPLL GFKDLCSRDM GFSCGTAFSG SFASSKDFDP GKFSQGPNNI 1680
SFSPKAPEMG VLHQSPFCSP PKPPSAPPLV TNVLCSEAPQ SYFLNLQSAA VHQSPNNRVS 1740
EIIMESVESS LPSDYSSRDA SSYLALEGAE DSLLGGSSFE TDTDEAAAFI ANDLLTSIET 1800
SSDEECAFCD EDQESPVPWA SLFALQTENG FWKLTPELGL ILNLNVNALL TSLEEKGIRS 1860
LGTKGRERLL DLIATLLVLQ FLYTKLEQEG MVAKSLIKMD DAFISRNIPW AFENIKKARE 1920
WARKTEGQYP SICQRLELGK DWESATKQLL GIQPQANTSL HRILYYSQG 1969 
Gene Ontology
 GO:0005737; C:cytoplasm; IEA:Compara.
 GO:0005634; C:nucleus; TAS:MGI.
 GO:0005819; C:spindle; TAS:MGI.
 GO:0005876; C:spindle microtubule; IEA:Compara.
 GO:0019899; F:enzyme binding; ISA:MGI.
 GO:0003950; F:NAD+ ADP-ribosyltransferase activity; IEA:Compara.
 GO:0008219; P:cell death; IEA:Compara.
 GO:0006954; P:inflammatory response; IEA:Compara.
 GO:0006471; P:protein ADP-ribosylation; IEA:InterPro. 
Interpro
 IPR001357; BRCT_dom.
 IPR009408; Formin_homology_1.
 IPR012317; Poly(ADP-ribose)pol_cat_dom.
 IPR004102; Poly(ADP-ribose)pol_reg_dom.
 IPR013694; VIT.
 IPR002035; VWF_A. 
Pfam
 PF00533; BRCT
 PF06346; Drf_FH1
 PF00644; PARP
 PF08487; VIT 
SMART
 SM00292; BRCT
 SM00609; VIT
 SM00327; VWA 
PROSITE
 PS50172; BRCT
 PS51060; PARP_ALPHA_HD
 PS51059; PARP_CATALYTIC
 PS51468; VIT
 PS50234; VWFA 
PRINTS