CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-034750
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Phosphodiesterase 6B, cGMP, rod receptor, beta polypeptide (Predicted) 
Protein Synonyms/Alias
 Protein Pde6b 
Gene Name
 Pde6b 
Gene Synonyms/Alias
 Pde6b_predicted; rCG_57187 
Created Date
 July 27, 2013 
Organism
 Rattus norvegicus (Rat) 
NCBI Taxa ID
 10116 
Lysine Modification
Position
Peptide
Type
References
487CEEDELGKILKEELPacetylation[1]
Reference
 [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405] 
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Hydrolase; Metal-binding; Receptor; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 856 AA 
Protein Sequence
MSLSEEQVRS FLDGNPTFAH QYFEKKLSPE NVAGACEGGC LVDCGSLREL CQVEESAALF 60
ELVQDMQESV NMERVVFKVL RRLCTILHAD RCSLFMYRQR NGVAELATRL FSVQPDSLLE 120
DCLVPPDSEI VFPLDIGIVG HVAQTKKMIN VQDVAECPHF SPFADELTDY VTKNILSTPI 180
MNGKDVVAVI MAVNKLDGPC FTSEDEDVFT KYLNFATLNL KIYHLSYLHN CETRRGQVLL 240
WSANKVFEEL TDIERQFHKA FYTVRAYLNC DRYSVGLLDM TKEKEFFDVW PVLMGEAQPY 300
SGPRTPDGRE IVFYKVIDYI LHGKEDIKVI PTPPADHWAL TSGLPTYVAE SGFICNIMNA 360
SADEMFNFQE GPLDESGWVI KNVLSMPIVN KKEEIVGVAT FYNRKDGKPF DDQDEVLMES 420
LTQFLGWSVL NTDTYDKMNK LENRKDIAQD MVLYHVRCDK DEIQEILPTR DRLGKEPADC 480
EEDELGKILK EELPGPTKFD IYEFHFSDLE CTELELVKCG IQMYYELGVV RKFQIPQEVL 540
VRFLFSVSKA YRRITYHNWR HGFNVAQTMF TLLMTGKLKS YYTDLEAFAM VTAGLCHDID 600
HRGTNNLYQM KSQNPLAKLH GSSILERHHL EFGKFLLAEE SLNIYQNLNR RQHEHVIHLM 660
DIAIIATDLA LYFKKRTMFQ KIVDESKNYE DKKSWVEYLS LETTRKEIVM AMMMTACDLS 720
AITKPWEVQS KVALLVAAEF WEQGDLERTV LDQQPIPMMD RNKAAELPKL QVGFIDFVCT 780
FVYKEFSRFH EEILPMFDRL QNNRKEWKAL ADEYEAKVKA LEEEKKKEED RVAAKKAGTE 840
ICNGGPAPKS STCCIL 856 
Gene Ontology
 GO:0047555; F:3',5'-cyclic-GMP phosphodiesterase activity; IEA:Compara.
 GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
 GO:0051480; P:cytosolic calcium ion homeostasis; IEA:Compara.
 GO:0009583; P:detection of light stimulus; IEA:Compara.
 GO:0046037; P:GMP metabolic process; IEA:Compara.
 GO:0060041; P:retina development in camera-type eye; IEA:Compara.
 GO:0007165; P:signal transduction; IEA:InterPro. 
Interpro
 IPR003018; GAF.
 IPR003607; HD/PDEase_dom.
 IPR023088; PDEase.
 IPR002073; PDEase_catalytic_dom.
 IPR023174; PDEase_CS. 
Pfam
 PF01590; GAF
 PF00233; PDEase_I 
SMART
 SM00065; GAF
 SM00471; HDc 
PROSITE
 PS00126; PDEASE_I 
PRINTS
 PR00387; PDIESTERASE1.