UniProt Accession

 RXRG_HUMAN; P48443; A6NIP1; Q6IBU7 

Genbank Protein ID

 U38480; CR456705; AL160058; CH471067; BC012063 

Genbank Nucleotide ID

 AAA80681.1; CAG32986.1; CAC00596.1; EAW90745.1; AAH12063.1 

Protein Name

 Retinoic acid receptor RXR-gamma 

Protein Synonyms/Alias

 Nuclear receptor subfamily 2 group B member 3; Retinoid X receptor gamma 

Gene Name

 RXRG 

Gene Synonyms/Alias

 NR2B3 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
10	GNYSHFMKFPAGYGG	methylation	[1]

Reference

 [1] Large-scale global identification of protein lysine methylation in vivo.
 Cao XJ, Arnaudo AM, Garcia BA.
 Epigenetics. 2013 May 1;8(5):477-85. [PMID: 23644510] 

Functional Description

 Receptor for retinoic acid. Retinoic acid receptors bind as heterodimers to their target response elements in response to their ligands, all-trans or 9-cis retinoic acid, and regulate gene expression in various biological processes. The RAR/RXR heterodimers bind to the retinoic acid response elements (RARE) composed of tandem 5'-AGGTCA-3' sites known as DR1-DR5. The high affinity ligand for RXRs is 9-cis retinoic acid (By similarity). 

Sequence Annotation

 DNA_BIND 136 211 Nuclear receptor.
 ZN_FING 139 159 NR C4-type.
 ZN_FING 175 199 NR C4-type.
 REGION 1 138 Modulating (By similarity).
 REGION 205 260 Hinge.
 REGION 261 463 Ligand-binding (By similarity).  

Keyword

 3D-structure; Complete proteome; DNA-binding; Metal-binding; Nucleus; Receptor; Reference proteome; Transcription; Transcription regulation; Zinc; Zinc-finger. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 463 AA 

Protein Sequence

Gene Ontology

 GO:0005654; C:nucleoplasm; TAS:Reactome.
 GO:0004886; F:9-cis retinoic acid receptor activity; TAS:ProtInc.
 GO:0043565; F:sequence-specific DNA binding; IEA:Compara.
 GO:0003707; F:steroid hormone receptor activity; IEA:InterPro.
 GO:0008270; F:zinc ion binding; IEA:InterPro.
 GO:0007507; P:heart development; IEA:Compara.
 GO:0030182; P:neuron differentiation; IEA:Compara.
 GO:0007422; P:peripheral nervous system development; IEA:Compara.
 GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; IEA:Compara.
 GO:0031641; P:regulation of myelination; IEA:Compara.
 GO:0032526; P:response to retinoic acid; IEA:Compara.
 GO:0007519; P:skeletal muscle tissue development; IEA:Compara.
 GO:0006367; P:transcription initiation from RNA polymerase II promoter; TAS:Reactome. 

Interpro

 IPR021780; Nuc_recep-AF1.
 IPR008946; Nucl_hormone_rcpt_ligand-bd.
 IPR000536; Nucl_hrmn_rcpt_lig-bd_core.
 IPR000003; Retinoid-X_rcpt/HNF4.
 IPR001723; Str_hrmn_rcpt.
 IPR001628; Znf_hrmn_rcpt.
 IPR013088; Znf_NHR/GATA. 

Pfam

 PF00104; Hormone_recep
 PF11825; Nuc_recep-AF1
 PF00105; zf-C4 

SMART

 SM00430; HOLI
 SM00399; ZnF_C4 

PROSITE

 PS00031; NUCLEAR_REC_DBD_1
 PS51030; NUCLEAR_REC_DBD_2 

PRINTS

 PR00545; RETINOIDXR.
 PR00398; STRDHORMONER.
 PR00047; STROIDFINGER.