CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-030755
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Polycystin-2 
Protein Synonyms/Alias
 cDNA FLJ50473, highly similar to Polycystin-2 
Gene Name
 PKD2 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
113KSDLAQQKAEMELSDubiquitination[1]
Reference
 [1] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 386 AA 
Protein Sequence
MSQLSTTMSR CAKDLFGFAI MFFIIFLAYA QLAYLVFGTQ VDDFSTFQEC IFTQFRIILG 60
DINFAEIEEA NRVLGPIYFT TFVFFMFFIL LNMFLAIIND TYSEVKSDLA QQKAEMELSD 120
LIRKGYHKAL VKLKLKKNTV DDISESLRQG GGKLNFDELR QDLKGKGHTD AEIEAIFTKY 180
DQDGDQELTE HEHQQMRDDL EKEREDLDLD HSSLPRPMSS RSFPRSLDDS EEDDDEDSGH 240
SSRRRGSISS GVSYEEFQVL VRRVDRMEHS IGSIVSKIDA VIVKLEIMER AKLKRREVLG 300
RLLDGVAEDE RLGRDSEIHR EQMERLVREE LERWESDDAA SQISHGLGTP VGLNGQPRPR 360
SSRPSSSQST EGMEGAGGNG SSNVHV 386 
Gene Ontology
 GO:0045180; C:basal cortex; IEA:Compara.
 GO:0005911; C:cell-cell junction; IEA:Compara.
 GO:0072686; C:mitotic spindle; IEA:Compara.
 GO:0031512; C:motile primary cilium; IEA:Compara.
 GO:0031513; C:nonmotile primary cilium; IEA:Compara.
 GO:0005886; C:plasma membrane; IEA:Compara.
 GO:0002133; C:polycystin complex; IEA:Compara.
 GO:0005509; F:calcium ion binding; IEA:Compara.
 GO:0005267; F:potassium channel activity; IEA:Compara.
 GO:0007050; P:cell cycle arrest; IEA:Compara.
 GO:0071498; P:cellular response to fluid shear stress; IEA:Compara.
 GO:0050982; P:detection of mechanical stimulus; IEA:Compara.
 GO:0003127; P:detection of nodal flow; IEA:Compara.
 GO:0001892; P:embryonic placenta development; IEA:Compara.
 GO:0007507; P:heart development; IEA:Compara.
 GO:0007259; P:JAK-STAT cascade; IEA:Compara.
 GO:0001822; P:kidney development; IEA:Compara.
 GO:0060315; P:negative regulation of ryanodine-sensitive calcium-release channel activity; IEA:Compara.
 GO:0060674; P:placenta blood vessel development; IEA:Compara.
 GO:0010628; P:positive regulation of gene expression; IEA:Compara.
 GO:0045429; P:positive regulation of nitric oxide biosynthetic process; IEA:Compara.
 GO:0030814; P:regulation of cAMP metabolic process; IEA:Compara.
 GO:0051209; P:release of sequestered calcium ion into cytosol; IEA:Compara.
 GO:0061333; P:renal tubule morphogenesis; IEA:Compara. 
Interpro
 IPR011992; EF-hand-like_dom.
 IPR002048; EF_hand_dom.
 IPR013122; PKD1_2_channel.
 IPR003915; PKD_2. 
Pfam
 PF08016; PKD_channel 
SMART
  
PROSITE
 PS50222; EF_HAND_2 
PRINTS
 PR01433; POLYCYSTIN2.