UniProt Accession

 NTM1A_HUMAN; Q9BV86; A8K4J2; A8K8G7; Q5SZB9; Q9UI28 

Genbank Protein ID

 AF110776; AK290957; AK292332; AK298840; AL590369; AL590369; BC001396; BC033234 

Genbank Nucleotide ID

 AAF14859.1; BAF83646.1; BAF85021.1; BAG60968.1; CAI14507.1; CAI14508.1; AAH01396.1; AAH33234.1 

Protein Name

 N-terminal Xaa-Pro-Lys N-methyltransferase 1 

Protein Synonyms/Alias

 Alpha N-terminal protein methyltransferase 1A; Methyltransferase-like protein 11A; N-terminal RCC1 methyltransferase; X-Pro-Lys N-terminal protein methyltransferase 1A; NTM1A; N-terminal Xaa-Pro-Lys N-methyltransferase 1, N-terminally processed 

Gene Name

 NTMT1 

Gene Synonyms/Alias

 C9orf32; METTL11A; NRMT; AD-003 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
109	TYLGEEGKRATSPIS	ubiquitination	[1]

Reference

 [1] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983] 

Functional Description

 Alpha-N-methyltransferase that methylates the N-terminus of target proteins containing the N-terminal motif [Ala/Pro/Ser]- Pro-Lys when the initiator Met is cleaved. Specifically catalyzes mono-, di- or tri-methylation of exposed alpha-amino group of Ala or Ser residue in the [Ala/Ser]-Pro-Lys motif and mono- or di- methylation of Pro in the Pro-Pro-Lys motif. Responsible for the N-terminal methylation of KLHL31, MYL2, MYL3, RB1, RCC1, RPL23A and SET. Required during mitosis for normal bipolar spindle formation and chromosome segregation via its action on RCC1. 

Sequence Annotation

 REGION 91 93 S-adenosyl-L-methionine binding.
 REGION 119 120 S-adenosyl-L-methionine binding.
 BINDING 69 69 S-adenosyl-L-methionine; via carbonyl
 BINDING 74 74 S-adenosyl-L-methionine.
 BINDING 135 135 S-adenosyl-L-methionine; via carbonyl
 MOD_RES 1 1 N-acetylmethionine.
 MOD_RES 2 2 N-acetylthreonine; in N-terminal Xaa-Pro-  

Keyword

 3D-structure; Acetylation; Alternative splicing; Complete proteome; Direct protein sequencing; Methyltransferase; Nucleus; Reference proteome; S-adenosyl-L-methionine; Transferase. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 223 AA 

Protein Sequence

Gene Ontology

 GO:0005737; C:cytoplasm; IDA:HPA.
 GO:0005634; C:nucleus; IDA:UniProtKB.
 GO:0008276; F:protein methyltransferase activity; IDA:UniProtKB.
 GO:0007059; P:chromosome segregation; IMP:UniProtKB.
 GO:0018012; P:N-terminal peptidyl-alanine trimethylation; IEA:Compara.
 GO:0018016; P:N-terminal peptidyl-proline dimethylation; IDA:UniProtKB.
 GO:0035572; P:N-terminal peptidyl-serine dimethylation; IDA:UniProtKB.
 GO:0035573; P:N-terminal peptidyl-serine trimethylation; IDA:UniProtKB.
 GO:0007051; P:spindle organization; IMP:UniProtKB. 

Interpro

 IPR008576; DUF858_MeTrfase_lik. 

Pfam

 PF05891; Methyltransf_PK 

SMART

  

PROSITE

  

PRINTS