UniProt Accession

 IMPA3_RAT; D4AD37 

Genbank Protein ID

 CH473984 

Genbank Nucleotide ID

 EDM11627.1 

Protein Name

 Inositol monophosphatase 3 

Protein Synonyms/Alias

 IMP 3; IMPase 3; Golgi 3-prime phosphoadenosine 5-prime phosphate 3-prime phosphatase; Golgi-resident PAP phosphatase; gPAPP; Inositol monophosphatase domain-containing protein 1; Inositol-1(or 4)-monophosphatase 3; Myo-inositol monophosphatase A3 

Gene Name

 Impad1 

Gene Synonyms/Alias

 Impa3 

Created Date

 July 27, 2013 

Organism

 Rattus norvegicus (Rat) 

NCBI Taxa ID

 10116 

Lysine Modification

Position	Peptide	Type	References
103	TREGAEDKMTSGDVL	acetylation	[1]
353	RKLPDLEKSGH****	acetylation	[1]

Reference

 [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405] 

Functional Description

 May play a role in the formation of skeletal elements derived through endochondral ossification, possibly by clearing adenosine 3',5'-bisphosphate produced by Golgi sulfotransferases during glycosaminoglycan sulfation (By similarity). 

Sequence Annotation

 REGION 174 177 Substrate binding (By similarity).
 METAL 131 131 Magnesium 1 (By similarity).
 METAL 172 172 Magnesium 1 (By similarity).
 METAL 172 172 Magnesium 2 (By similarity).
 METAL 174 174 Magnesium 1; via carbonyl oxygen (By
 METAL 175 175 Magnesium 2 (By similarity).
 METAL 298 298 Magnesium 2 (By similarity).
 BINDING 131 131 Substrate (By similarity).
 BINDING 298 298 Substrate (By similarity).
 CARBOHYD 257 257 N-linked (GlcNAc...) (Probable).  

Keyword

 Complete proteome; Glycoprotein; Golgi apparatus; Hydrolase; Magnesium; Membrane; Metal-binding; Reference proteome; Signal-anchor; Transmembrane; Transmembrane helix. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 356 AA 

Protein Sequence

Gene Ontology

 GO:0005794; C:Golgi apparatus; IEA:UniProtKB-SubCell.
 GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
 GO:0008441; F:3'(2'),5'-bisphosphate nucleotidase activity; IEA:EC.
 GO:0008934; F:inositol monophosphate 1-phosphatase activity; IEA:EC.
 GO:0052832; F:inositol monophosphate 3-phosphatase activity; IEA:EC.
 GO:0052833; F:inositol monophosphate 4-phosphatase activity; IEA:EC.
 GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
 GO:0006021; P:inositol biosynthetic process; IEA:UniProtKB-UniPathway.
 GO:0046854; P:phosphatidylinositol phosphorylation; IEA:InterPro. 

Interpro

 IPR000760; Inositol_monophosphatase.
 IPR020550; Inositol_monophosphatase_CS. 

Pfam

 PF00459; Inositol_P 

SMART

  

PROSITE

 PS00630; IMP_2 

PRINTS