UniProt Accession

 TAGL_RAT; P31232 

Genbank Protein ID

 X71070; M83107; X64422; BC061770 

Genbank Nucleotide ID

 CAA50396.1; AAA40762.1; CAA45769.1; AAH61770.1 

Protein Name

 Transgelin 

Protein Synonyms/Alias

 Smooth muscle protein 22-alpha; SM22-alpha 

Gene Name

 Tagln 

Gene Synonyms/Alias

 Sm22 

Created Date

 July 27, 2013 

Organism

 Rattus norvegicus (Rat) 

NCBI Taxa ID

 10116 

Lysine Modification

Position	Peptide	Type	References
4	****MANKGPSYGMS	acetylation	[1]
17	MSREVQSKIEKKYDE	acetylation	[1]
20	EVQSKIEKKYDEELE	acetylation	[1]
21	VQSKIEKKYDEELEE	acetylation	[1]
75	SLYPEGSKPVKVPEN	acetylation	[1]
78	PEGSKPVKVPENPPS	acetylation	[1]
89	NPPSMVFKQMEQVAQ	acetylation	[1]
99	EQVAQFLKAAEDYGV	acetylation	[1]
108	AEDYGVTKTDMFQTV	acetylation	[1]
121	TVDLFEGKDMAAVQR	acetylation	[1]
154	GDPNWFMKKAQEHKR	acetylation	[1]
172	DSQLQEGKHVIGLQM	acetylation	[1]

Reference

 [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405] 

Functional Description

 Actin cross-linking/gelling protein. 

Sequence Annotation

 DOMAIN 24 137 CH.
 REPEAT 175 200 Calponin-like.
 REGION 154 161 Could be involved in actin-binding.
 MOD_RES 2 2 N-acetylalanine (Potential).
 MOD_RES 166 166 Phosphoserine (By similarity).  

Keyword

 Acetylation; Complete proteome; Cytoplasm; Direct protein sequencing; Muscle protein; Phosphoprotein; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 201 AA 

Protein Sequence

Gene Ontology

 GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
 GO:0051015; F:actin filament binding; TAS:RGD.
 GO:0030674; F:protein binding, bridging; TAS:RGD.
 GO:0007517; P:muscle organ development; IEA:InterPro. 

Interpro

 IPR000557; Calponin_repeat.
 IPR001715; CH-domain.
 IPR003096; SM22_calponin.
 IPR001061; TAGLN. 

Pfam

 PF00402; Calponin
 PF00307; CH 

SMART

 SM00033; CH 

PROSITE

 PS01052; CALPONIN_1
 PS51122; CALPONIN_2
 PS50021; CH 

PRINTS

 PR00888; SM22CALPONIN.